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Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor.

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Title: Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor.
Authors: Yang Z; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Han S; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China., Keller M; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany. max.keller@chemie.uni-regensburg.de., Kaiser A; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany., Bender BJ; Department of Pharmacology, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA., Bosse M; Institute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany., Burkert K; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany., Kögler LM; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany., Wifling D; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Bernhardt G; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Plank N; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Littmann T; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Schmidt P; Institute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany., Yi C; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Li B; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China., Ye S; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China., Zhang R; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; National Center for Protein Science Shanghai, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China., Xu B; Department of Neuroscience, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Larhammar D; Department of Neuroscience, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Stevens RC; iHuman Institute, ShanghaiTech University, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Huster D; Institute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany., Meiler J; Department of Pharmacology, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.; Departments of Chemistry and Bioinformatics, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA., Zhao Q; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.; Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Chinese Academy of Sciences, Beijing, China., Beck-Sickinger AG; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany. abeck-sickinger@uni-leipzig.de., Buschauer A; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Wu B; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. beiliwu@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. beiliwu@simm.ac.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China. beiliwu@simm.ac.cn.; Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Chinese Academy of Sciences, Beijing, China. beiliwu@simm.ac.cn.
Source: Nature [Nature] 2018 Apr; Vol. 556 (7702), pp. 520-524. Date of Electronic Publication: 2018 Apr 18.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structural basis of ligand binding modes at the neuropeptide Y Y<subscript>1</subscript> receptor.
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  Data: <searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Han+S%22">Han S</searchLink>; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Keller+M%22">Keller M</searchLink>; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany. max.keller@chemie.uni-regensburg.de.<br /><searchLink fieldCode="AU" term="%22Kaiser+A%22">Kaiser A</searchLink>; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Bender+BJ%22">Bender BJ</searchLink>; Department of Pharmacology, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Bosse+M%22">Bosse M</searchLink>; Institute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Burkert+K%22">Burkert K</searchLink>; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Kögler+LM%22">Kögler LM</searchLink>; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Wifling+D%22">Wifling D</searchLink>; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bernhardt+G%22">Bernhardt G</searchLink>; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Plank+N%22">Plank N</searchLink>; 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National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; National Center for Protein Science Shanghai, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xu+B%22">Xu B</searchLink>; Department of Neuroscience, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Larhammar+D%22">Larhammar D</searchLink>; Department of Neuroscience, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Stevens+RC%22">Stevens RC</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Huster+D%22">Huster D</searchLink>; Institute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Meiler+J%22">Meiler J</searchLink>; Department of Pharmacology, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.; Departments of Chemistry and Bioinformatics, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+Q%22">Zhao Q</searchLink>; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.; Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Beck-Sickinger+AG%22">Beck-Sickinger AG</searchLink>; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany. abeck-sickinger@uni-leipzig.de.<br /><searchLink fieldCode="AU" term="%22Buschauer+A%22">Buschauer A</searchLink>; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wu+B%22">Wu B</searchLink>; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. beiliwu@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. beiliwu@simm.ac.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China. beiliwu@simm.ac.cn.; Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Chinese Academy of Sciences, Beijing, China. beiliwu@simm.ac.cn.
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