Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor.

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Title: Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor.
Authors: Yang Z; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Han S; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China., Keller M; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany. max.keller@chemie.uni-regensburg.de., Kaiser A; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany., Bender BJ; Department of Pharmacology, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA., Bosse M; Institute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany., Burkert K; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany., Kögler LM; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany., Wifling D; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Bernhardt G; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Plank N; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Littmann T; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Schmidt P; Institute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany., Yi C; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Li B; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China., Ye S; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China., Zhang R; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; National Center for Protein Science Shanghai, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China., Xu B; Department of Neuroscience, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Larhammar D; Department of Neuroscience, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Stevens RC; iHuman Institute, ShanghaiTech University, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Huster D; Institute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany., Meiler J; Department of Pharmacology, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.; Departments of Chemistry and Bioinformatics, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA., Zhao Q; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.; Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Chinese Academy of Sciences, Beijing, China., Beck-Sickinger AG; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany. abeck-sickinger@uni-leipzig.de., Buschauer A; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Wu B; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. beiliwu@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. beiliwu@simm.ac.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China. beiliwu@simm.ac.cn.; Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Chinese Academy of Sciences, Beijing, China. beiliwu@simm.ac.cn.
Source: Nature [Nature] 2018 Apr; Vol. 556 (7702), pp. 520-524. Date of Electronic Publication: 2018 Apr 18.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-018-0046-x