Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.
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| Title: | Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice. |
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| Authors: | Deepa SS; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Pharaoh G; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma., Kinter M; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Diaz V; Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas., Fok WC; Division of Hematology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Riddle K; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Pulliam D; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.; Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas., Hill S; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.; Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas., Fischer KE; Biology Department, University of Alabama at Birmingham, Birmingham, Alabama., Soto V; Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas., Georgescu C; Arthritis & Clinical Immunology Research Program, Division of Genomics and Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Wren JD; Arthritis & Clinical Immunology Research Program, Division of Genomics and Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Viscomi C; MRC-Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Richardson A; Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma., Van Remmen H; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma. |
| Source: | Aging cell [Aging Cell] 2018 Aug; Vol. 17 (4), pp. e12769. Date of Electronic Publication: 2018 Apr 25. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1474-9726 |
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| DOI: | 10.1111/acel.12769 |
