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Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.

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Title: Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.
Authors: Deepa SS; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Pharaoh G; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma., Kinter M; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Diaz V; Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas., Fok WC; Division of Hematology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri., Riddle K; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Pulliam D; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.; Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas., Hill S; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.; Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas., Fischer KE; Biology Department, University of Alabama at Birmingham, Birmingham, Alabama., Soto V; Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas., Georgescu C; Arthritis & Clinical Immunology Research Program, Division of Genomics and Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Wren JD; Arthritis & Clinical Immunology Research Program, Division of Genomics and Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Viscomi C; MRC-Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Richardson A; Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma., Van Remmen H; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma.
Source: Aging cell [Aging Cell] 2018 Aug; Vol. 17 (4), pp. e12769. Date of Electronic Publication: 2018 Apr 25.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.
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  Data: <searchLink fieldCode="AU" term="%22Deepa+SS%22">Deepa SS</searchLink>; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.<br /><searchLink fieldCode="AU" term="%22Pharaoh+G%22">Pharaoh G</searchLink>; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.<br /><searchLink fieldCode="AU" term="%22Kinter+M%22">Kinter M</searchLink>; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.<br /><searchLink fieldCode="AU" term="%22Diaz+V%22">Diaz V</searchLink>; Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Fok+WC%22">Fok WC</searchLink>; Division of Hematology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.<br /><searchLink fieldCode="AU" term="%22Riddle+K%22">Riddle K</searchLink>; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.<br /><searchLink fieldCode="AU" term="%22Pulliam+D%22">Pulliam D</searchLink>; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.; Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Hill+S%22">Hill S</searchLink>; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.; Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Fischer+KE%22">Fischer KE</searchLink>; Biology Department, University of Alabama at Birmingham, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Soto+V%22">Soto V</searchLink>; Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Georgescu+C%22">Georgescu C</searchLink>; Arthritis & Clinical Immunology Research Program, Division of Genomics and Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.<br /><searchLink fieldCode="AU" term="%22Wren+JD%22">Wren JD</searchLink>; Arthritis & Clinical Immunology Research Program, Division of Genomics and Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.<br /><searchLink fieldCode="AU" term="%22Viscomi+C%22">Viscomi C</searchLink>; MRC-Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Richardson+A%22">Richardson A</searchLink>; Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma.<br /><searchLink fieldCode="AU" term="%22Van+Remmen+H%22">Van Remmen H</searchLink>; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma.
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