A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

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Title: A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
Authors: van Zuydam NR; Wellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K. nvanzuy@well.ox.ac.uk.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K., Ahlqvist E; Diabetes and Endocrinology, Department of Clinical Sciences, Lund University, Malmö, Sweden., Sandholm N; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Diabetes and Obesity Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland., Deshmukh H; Newcastle University, Newcastle, U.K., Rayner NW; Wellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.; Human Genetics Programme, Wellcome Sanger Institute, University of Cambridge, Cambridge, U.K., Abdalla M; Wellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.; Department of Statistics, University of Oxford, Oxford, U.K., Ladenvall C; Diabetes and Endocrinology, Department of Clinical Sciences, Lund University, Malmö, Sweden., Ziemek D; Inflammation and Immunology Research Unit, Pfizer, Berlin, Germany., Fauman E; Computational Target Validation, Pfizer, Cambridge, MA., Robertson NR; Wellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K., McKeigue PM; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, U.K., Valo E; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Diabetes and Obesity Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland., Forsblom C; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Diabetes and Obesity Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland., Harjutsalo V; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Diabetes and Obesity Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.; Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland., Perna A; Clinical Research Center for Rare Diseases 'Aldo e Cele Daccò,' Istituto di Ricerche Farmacologiche 'Mario Negri,' Bergamo, Italy., Rurali E; Clinical Research Center for Rare Diseases 'Aldo e Cele Daccò,' Istituto di Ricerche Farmacologiche 'Mario Negri,' Bergamo, Italy., Marcovecchio ML; Department of Paediatrics, University of Cambridge, Cambridge, U.K., Igo RP Jr; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH., Salem RM; Department of Family Medicine and Public Health, University of California, San Diego, San Diego, CA., Perico N; Clinical Research Center for Rare Diseases 'Aldo e Cele Daccò,' Istituto di Ricerche Farmacologiche 'Mario Negri,' Bergamo, Italy., Lajer M; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Käräjämäki A; Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.; Diabetes Center, Vaasa Health Care Center, Vaasa, Finland., Imamura M; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.; Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara, Japan.; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Takahashi A; Department of Genomic Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Sim X; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Liu J; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Division of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Jiang G; Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Tam CHT; Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Luk AOY; Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Lee HM; Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.; Integrated Bioinformatics Laboratory for Cancer and Metabolic Diseases, The Chinese University of Hong Kong, Hong Kong, China., Lim CKP; Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Szeto CC; Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., So WY; Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Chan JCN; Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Ang SF; Clinical Research Unit, Khoo Teck Puat Hospital, National Healthcare Group, Singapore., Dorajoo R; Division of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore., Wang L; Division of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore., Clara TSH; Clinical Research Unit, Khoo Teck Puat Hospital, National Healthcare Group, Singapore., McKnight AJ; Centre for Public Health, Queen's University Belfast, Belfast, U.K., Duffy S; Centre for Public Health, Queen's University Belfast, Belfast, U.K., Pezzolesi MG; Division of Nephrology and Hypertension and Diabetes & Metabolism Research Center, University of Utah Health, Salt Lake City, UT., Marre M; Sorbonnes Université, University Pierre and Marie Curie, INSERM UMRS 1166, Institute for Cardiometabolism and Nutrition, Department of Genomics and Pathophysiology of Cardiovascular Diseases, Paris, France., Gyorgy B; Sorbonnes Université, University Pierre and Marie Curie, INSERM UMRS 1166, Institute for Cardiometabolism and Nutrition, Department of Genomics and Pathophysiology of Cardiovascular Diseases, Paris, France., Hadjadj S; Endocrinology-Diabetology, Centre Hospitalier Universitaire de Poitiers, Poitiers, France.; Clinical Investigation Center 1402 and U1082, INSERM, University of Poitiers, Poitiers, France.; Faculté de Médecine et de Pharmacie, University of Poitiers, Poitiers, France., Hiraki LT; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Canada., Ahluwalia TS; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Almgren P; Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences, Lund University, Malmö, Sweden., Schulz CA; Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences, Lund University, Malmö, Sweden., Orho-Melander M; Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences, Lund University, Malmö, Sweden., Linneberg A; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Christensen C; Department of Internal Medicine and Endocrinology, Vejle Hospital, Vejle, Denmark., Witte DR; Department of Public Health, Aarhus University, Aarhus, Denmark.; Danish Diabetes Academy, Odense, Denmark., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brandslund I; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark., Melander O; Hypertension and Cardiovascular Disease, Department of Clinical Sciences, Lund University, Malmö, Sweden., Paterson AD; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Canada., Tregouet D; Sorbonnes Université, University Pierre and Marie Curie, INSERM UMRS 1166, Institute for Cardiometabolism and Nutrition, Department of Genomics and Pathophysiology of Cardiovascular Diseases, Paris, France., Maxwell AP; Centre for Public Health, Queen's University Belfast, Belfast, U.K., Lim SC; Diabetes Centre, Clinical Research Unit, Department of Medicine, Khoo Teck Puat Hospital, National Healthcare Group, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Ma RCW; Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.; Integrated Bioinformatics Laboratory for Cancer and Metabolic Diseases, The Chinese University of Hong Kong, Hong Kong, China., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore., Maeda S; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.; Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara, Japan.; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Lyssenko V; Diabetes and Endocrinology, Department of Clinical Sciences, Lund University, Malmö, Sweden.; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Norway., Tuomi T; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Diabetes and Obesity Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.; Abdominal Center Endocrinology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Krolewski AS; Joslin Diabetes Center, Harvard Medical School, Boston, MA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA., Hirschhorn JN; Center for Basic and Translational Obesity Research and Division of Endocrinology, Boston Children's Hospital, Boston, MA.; Programs in Medical and Population Genetics and Metabolism, Broad Institute, Cambridge, MA.; Department of Genetics, Harvard Medical School, Boston, MA., Florez JC; Programs in Medical and Population Genetics and Metabolism, Broad Institute, Cambridge, MA.; Diabetes Clinical Research Center, Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Dunger D; Department of Paediatrics, University of Cambridge, Cambridge, U.K.; Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, U.K., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Rossing P; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Remuzzi G; Clinical Research Center for Rare Diseases 'Aldo e Cele Daccò,' Istituto di Ricerche Farmacologiche 'Mario Negri,' Bergamo, Italy.; Unit of Nephrology and Dialysis, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy., Brosnan MJ; Cardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer, Cambridge, MA., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, U.K., Groop PH; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Diabetes and Obesity Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.; Baker IDI Heart and Diabetes Institute, Melbourne, Australia., Colhoun HM; Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, U.K., Groop LC; Diabetes and Endocrinology, Department of Clinical Sciences, Lund University, Malmö, Sweden.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., McCarthy MI; Wellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.; National Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, U.K.
Corporate Authors: Finnish Diabetic Nephropathy Study (FinnDiane), Hong Kong Diabetes Registry Theme-based Research Scheme Project Group, Warren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group, GENIE (GEnetics of Nephropathy an International Effort) Consortium, Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group, SUrrogate markers for Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium
Source: Diabetes [Diabetes] 2018 Jul; Vol. 67 (7), pp. 1414-1427. Date of Electronic Publication: 2018 Apr 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1939-327X
DOI:10.2337/db17-0914