Evaluation of the Efficacy, Safety, and Tolerability of BI 409306, a Novel Phosphodiesterase 9 Inhibitor, in Cognitive Impairment in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled, Phase II Trial.

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Title: Evaluation of the Efficacy, Safety, and Tolerability of BI 409306, a Novel Phosphodiesterase 9 Inhibitor, in Cognitive Impairment in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled, Phase II Trial.
Authors: Brown D; Community Clinical Research, Inc, Austin, TX., Nakagome K; Department of Forensic Psychiatry, National Center of Neurology and Psychiatry, Kodaira, Japan., Cordes J; Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany., Brenner R; Neurobehavioral Research, Inc, New York, NY., Gründer G; Department of Molecular Neuroimaging, Central Institute of Mental Health, Clinical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Keefe RSE; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC., Riesenberg R; Atlanta Center for Medical Research, Atlanta, GA., Walling DP; CNS Network, Inc, Garden Grove, CA., Daniels K; Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT., Wang L; Boehringer Ingelheim Taiwan Limited, Taipei, Taiwan., McGinniss J; Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT., Sand M; Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT.
Source: Schizophrenia bulletin [Schizophr Bull] 2019 Mar 07; Vol. 45 (2), pp. 350-359.
Publication Type: Adaptive Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0236760 Publication Model: Print Cited Medium: Internet ISSN: 1745-1701 (Electronic) Linking ISSN: 05867614 NLM ISO Abbreviation: Schizophr Bull Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1745-1701
DOI:10.1093/schbul/sby049