Targeting Serotonin 2A and Adrenergic α1 Receptors for Ocular Antihypertensive Agents: Discovery of 3,4-Dihydropyrazino[1,2-b]indazol-1(2H)-one Derivatives.
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| Title: | Targeting Serotonin 2A and Adrenergic α |
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| Authors: | Furlotti G; Angelini RR&D (Research, Regulatory & Development), Angelini S.p.A., Piazzale della stazione snc, 00071, S. Palomba-Pomezia (Rome), Italy., Alisi MA; Angelini RR&D (Research, Regulatory & Development), Angelini S.p.A., Piazzale della stazione snc, 00071, S. Palomba-Pomezia (Rome), Italy., Cazzolla N; Angelini RR&D (Research, Regulatory & Development), Angelini S.p.A., Piazzale della stazione snc, 00071, S. Palomba-Pomezia (Rome), Italy., Ceccacci F; Chemistry Department 'S. Cannizzaro', University of Rome 'La Sapienza', P.le Aldo Moro 5, 00185, Rome, Italy.; Current affiliation: Istituto di Metodologie Chimiche-CNR, Unità Organizzativa di Supporto, Sede di Roma, Università degli Studi di Roma 'La Sapienza', P. le Aldo Moro 5, 00185, Rome, Italy)., Garrone B; Angelini RR&D (Research, Regulatory & Development), Angelini S.p.A., Piazzale della stazione snc, 00071, S. Palomba-Pomezia (Rome), Italy., Gasperi T; Department of Science, Section of Nanoscience and Nanotechnology, University of Roma Tre, via della Vasca Navale 79, 00146, Rome, Italy., La Bella A; Chemistry Department 'S. Cannizzaro', University of Rome 'La Sapienza', P.le Aldo Moro 5, 00185, Rome, Italy., Leonelli F; Chemistry Department 'S. Cannizzaro', University of Rome 'La Sapienza', P.le Aldo Moro 5, 00185, Rome, Italy.; Dipartimento di Biologia Ambientale, University of Rome 'La Sapienza', P.le Aldo Moro 5, 00185, Rome, Italy., Loreto MA; Chemistry Department 'S. Cannizzaro', University of Rome 'La Sapienza', P.le Aldo Moro 5, 00185, Rome, Italy., Magarò G; Angelini RR&D (Research, Regulatory & Development), Angelini S.p.A., Piazzale della stazione snc, 00071, S. Palomba-Pomezia (Rome), Italy., Mangano G; Angelini RR&D (Research, Regulatory & Development), Angelini S.p.A., Piazzale della stazione snc, 00071, S. Palomba-Pomezia (Rome), Italy., Bettolo RM; Chemistry Department 'S. Cannizzaro', University of Rome 'La Sapienza', P.le Aldo Moro 5, 00185, Rome, Italy., Masini E; Departments of NEUROFARBA, Section of Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy., Miceli M; Department of Science, Section of Nanoscience and Nanotechnology, University of Roma Tre, via della Vasca Navale 79, 00146, Rome, Italy., Migneco LM; Chemistry Department 'S. Cannizzaro', University of Rome 'La Sapienza', P.le Aldo Moro 5, 00185, Rome, Italy., Vitiello M; Angelini RR&D (Research, Regulatory & Development), Angelini S.p.A., Piazzale della stazione snc, 00071, S. Palomba-Pomezia (Rome), Italy. |
| Source: | ChemMedChem [ChemMedChem] 2018 Aug 10; Vol. 13 (15), pp. 1597-1607. Date of Electronic Publication: 2018 Jul 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1860-7187 |
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| DOI: | 10.1002/cmdc.201800199 |
