Deciphering Specificity Determinants for FR900359-Derived Gq α Inhibitors Based on Computational and Structure-Activity Studies.
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| Title: | Deciphering Specificity Determinants for FR900359-Derived G |
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| Authors: | Reher R; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Kühl T; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Annala S; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Benkel T; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Kaufmann D; Eduard Zintl Institute for Inorganic and Physical Chemistry, Technische Universität Darmstadt, Alarich-Weiss-Str. 4, 64287, Darmstadt, Germany., Nubbemeyer B; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Odhiambo JP; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Heimer P; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Bäuml CA; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Kehraus S; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Crüsemann M; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Kostenis E; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Tietze D; Eduard Zintl Institute for Inorganic and Physical Chemistry, Technische Universität Darmstadt, Alarich-Weiss-Str. 4, 64287, Darmstadt, Germany., König GM; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Imhof D; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany. |
| Source: | ChemMedChem [ChemMedChem] 2018 Aug 20; Vol. 13 (16), pp. 1634-1643. Date of Electronic Publication: 2018 Jul 03. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1860-7187 |
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| DOI: | 10.1002/cmdc.201800304 |