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Deciphering Specificity Determinants for FR900359-Derived Gq α Inhibitors Based on Computational and Structure-Activity Studies.

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Title: Deciphering Specificity Determinants for FR900359-Derived Gq α Inhibitors Based on Computational and Structure-Activity Studies.
Authors: Reher R; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Kühl T; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Annala S; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Benkel T; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Kaufmann D; Eduard Zintl Institute for Inorganic and Physical Chemistry, Technische Universität Darmstadt, Alarich-Weiss-Str. 4, 64287, Darmstadt, Germany., Nubbemeyer B; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Odhiambo JP; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Heimer P; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Bäuml CA; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Kehraus S; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Crüsemann M; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Kostenis E; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Tietze D; Eduard Zintl Institute for Inorganic and Physical Chemistry, Technische Universität Darmstadt, Alarich-Weiss-Str. 4, 64287, Darmstadt, Germany., König GM; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany., Imhof D; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.
Source: ChemMedChem [ChemMedChem] 2018 Aug 20; Vol. 13 (16), pp. 1634-1643. Date of Electronic Publication: 2018 Jul 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem
Database: MEDLINE Ultimate
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  Data: Deciphering Specificity Determinants for FR900359-Derived G<subscript>q</subscript> α Inhibitors Based on Computational and Structure-Activity Studies.
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  Data: <searchLink fieldCode="AU" term="%22Reher+R%22">Reher R</searchLink>; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kühl+T%22">Kühl T</searchLink>; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Annala+S%22">Annala S</searchLink>; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Benkel+T%22">Benkel T</searchLink>; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kaufmann+D%22">Kaufmann D</searchLink>; Eduard Zintl Institute for Inorganic and Physical Chemistry, Technische Universität Darmstadt, Alarich-Weiss-Str. 4, 64287, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Nubbemeyer+B%22">Nubbemeyer B</searchLink>; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Odhiambo+JP%22">Odhiambo JP</searchLink>; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Heimer+P%22">Heimer P</searchLink>; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Bäuml+CA%22">Bäuml CA</searchLink>; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kehraus+S%22">Kehraus S</searchLink>; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Crüsemann+M%22">Crüsemann M</searchLink>; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kostenis+E%22">Kostenis E</searchLink>; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Tietze+D%22">Tietze D</searchLink>; Eduard Zintl Institute for Inorganic and Physical Chemistry, Technische Universität Darmstadt, Alarich-Weiss-Str. 4, 64287, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22König+GM%22">König GM</searchLink>; Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Imhof+D%22">Imhof D</searchLink>; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101259013%22">ChemMedChem</searchLink> [ChemMedChem] 2018 Aug 20; Vol. 13 (16), pp. 1634-1643. <i>Date of Electronic Publication: </i>2018 Jul 03.
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