Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28.

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Title: Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28.
Authors: Wang L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Rowe RG; Stem Cell Program, Boston Children's Hospital, Boston, MA, USA; Department of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA, USA., Jaimes A; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Yu C; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Nam Y; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Pearson DS; Stem Cell Program, Boston Children's Hospital, Boston, MA, USA., Zhang J; Stem Cell Program, Boston Children's Hospital, Boston, MA, USA., Xie X; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Marion W; Stem Cell Program, Boston Children's Hospital, Boston, MA, USA., Heffron GJ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Daley GQ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Stem Cell Program, Boston Children's Hospital, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA; Division of Hematology, Brigham and Women's Hospital, Boston, MA, USA; Manton Center for Orphan Disease Research, Boston, MA, USA., Sliz P; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA. Electronic address: sliz@hkl.hms.harvard.edu.
Source: Cell reports [Cell Rep] 2018 Jun 05; Vol. 23 (10), pp. 3091-3101.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2018.04.116