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High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.

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Bibliographic Details
Title: High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.
Authors: Coussens NP; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Kales SC; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Henderson MJ; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Lee OW; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Horiuchi KY; the Reaction Biology Corporation, Malvern, Pennsylvania 19355., Wang Y; the Reaction Biology Corporation, Malvern, Pennsylvania 19355., Chen Q; the Reaction Biology Corporation, Malvern, Pennsylvania 19355., Kuznetsova E; the Reaction Biology Corporation, Malvern, Pennsylvania 19355., Wu J; the Reaction Biology Corporation, Malvern, Pennsylvania 19355., Chakka S; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Cheff DM; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Cheng KC; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Shinn P; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Brimacombe KR; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Shen M; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Simeonov A; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Lal-Nag M; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Ma H; the Reaction Biology Corporation, Malvern, Pennsylvania 19355., Jadhav A; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Hall MD; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and hallma@mail.nih.gov.
Source: The Journal of biological chemistry [J Biol Chem] 2018 Aug 31; Vol. 293 (35), pp. 13750-13765. Date of Electronic Publication: 2018 Jun 26.
Publication Type: Journal Article; Research Support, N.I.H., Intramural
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1083-351X
DOI:10.1074/jbc.RA118.004274