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High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.

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Title: High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.
Authors: Coussens NP; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Kales SC; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Henderson MJ; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Lee OW; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Horiuchi KY; the Reaction Biology Corporation, Malvern, Pennsylvania 19355., Wang Y; the Reaction Biology Corporation, Malvern, Pennsylvania 19355., Chen Q; the Reaction Biology Corporation, Malvern, Pennsylvania 19355., Kuznetsova E; the Reaction Biology Corporation, Malvern, Pennsylvania 19355., Wu J; the Reaction Biology Corporation, Malvern, Pennsylvania 19355., Chakka S; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Cheff DM; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Cheng KC; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Shinn P; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Brimacombe KR; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Shen M; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Simeonov A; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Lal-Nag M; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Ma H; the Reaction Biology Corporation, Malvern, Pennsylvania 19355., Jadhav A; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and., Hall MD; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and hallma@mail.nih.gov.
Source: The Journal of biological chemistry [J Biol Chem] 2018 Aug 31; Vol. 293 (35), pp. 13750-13765. Date of Electronic Publication: 2018 Jun 26.
Publication Type: Journal Article; Research Support, N.I.H., Intramural
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.
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  Data: <searchLink fieldCode="AU" term="%22Coussens+NP%22">Coussens NP</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.<br /><searchLink fieldCode="AU" term="%22Kales+SC%22">Kales SC</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.<br /><searchLink fieldCode="AU" term="%22Henderson+MJ%22">Henderson MJ</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.<br /><searchLink fieldCode="AU" term="%22Lee+OW%22">Lee OW</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.<br /><searchLink fieldCode="AU" term="%22Horiuchi+KY%22">Horiuchi KY</searchLink>; the Reaction Biology Corporation, Malvern, Pennsylvania 19355.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; the Reaction Biology Corporation, Malvern, Pennsylvania 19355.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; the Reaction Biology Corporation, Malvern, Pennsylvania 19355.<br /><searchLink fieldCode="AU" term="%22Kuznetsova+E%22">Kuznetsova E</searchLink>; the Reaction Biology Corporation, Malvern, Pennsylvania 19355.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; the Reaction Biology Corporation, Malvern, Pennsylvania 19355.<br /><searchLink fieldCode="AU" term="%22Chakka+S%22">Chakka S</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.<br /><searchLink fieldCode="AU" term="%22Cheff+DM%22">Cheff DM</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.<br /><searchLink fieldCode="AU" term="%22Cheng+KC%22">Cheng KC</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.<br /><searchLink fieldCode="AU" term="%22Shinn+P%22">Shinn P</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.<br /><searchLink fieldCode="AU" term="%22Brimacombe+KR%22">Brimacombe KR</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.<br /><searchLink fieldCode="AU" term="%22Shen+M%22">Shen M</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.<br /><searchLink fieldCode="AU" term="%22Simeonov+A%22">Simeonov A</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.<br /><searchLink fieldCode="AU" term="%22Lal-Nag+M%22">Lal-Nag M</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.<br /><searchLink fieldCode="AU" term="%22Ma+H%22">Ma H</searchLink>; the Reaction Biology Corporation, Malvern, Pennsylvania 19355.<br /><searchLink fieldCode="AU" term="%22Jadhav+A%22">Jadhav A</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.<br /><searchLink fieldCode="AU" term="%22Hall+MD%22">Hall MD</searchLink>; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and hallma@mail.nih.gov.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2018 Aug 31; Vol. 293 (35), pp. 13750-13765. <i>Date of Electronic Publication: </i>2018 Jun 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1074/jbc.RA118.004274
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        Text: English
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        StartPage: 13750
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      – TitleFull: High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.
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              Text: 2018 Aug 31
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