A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers.

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Title: A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers.
Authors: Gettinger SN; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA., Choi J; Department of Genetics, Yale School of Medicine, New Haven, CT, 06511, USA., Mani N; Department of Pathology, Yale School of Medicine, New Haven, CT, 06511, USA.; Translational Immuno-oncology Laboratory, Yale Cancer Center, New Haven, CT, 06511, USA., Sanmamed MF; Immunobiology, Yale School of Medicine, New Haven, CT, 06511, USA., Datar I; Department of Pathology, Yale School of Medicine, New Haven, CT, 06511, USA.; Translational Immuno-oncology Laboratory, Yale Cancer Center, New Haven, CT, 06511, USA., Sowell R; Immunobiology, Yale School of Medicine, New Haven, CT, 06511, USA., Du VY; Immunobiology, Yale School of Medicine, New Haven, CT, 06511, USA., Kaftan E; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA.; Translational Immuno-oncology Laboratory, Yale Cancer Center, New Haven, CT, 06511, USA., Goldberg S; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA., Dong W; Department of Genetics, Yale School of Medicine, New Haven, CT, 06511, USA., Zelterman D; Yale School of Public Health, New Haven, CT, 06511, USA., Politi K; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA.; Department of Pathology, Yale School of Medicine, New Haven, CT, 06511, USA., Kavathas P; Immunobiology, Yale School of Medicine, New Haven, CT, 06511, USA.; Laboratory Medicine, Yale School of Medicine, New Haven, CT, 06511, USA., Kaech S; Immunobiology, Yale School of Medicine, New Haven, CT, 06511, USA., Yu X; Yale School of Public Health, New Haven, CT, 06511, USA., Zhao H; Department of Genetics, Yale School of Medicine, New Haven, CT, 06511, USA.; Yale School of Public Health, New Haven, CT, 06511, USA., Schlessinger J; Department of Pharmacology, Yale School of Medicine, New Haven, CT, 06511, USA., Lifton R; Department of Genetics, Yale School of Medicine, New Haven, CT, 06511, USA., Rimm DL; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA.; Department of Pathology, Yale School of Medicine, New Haven, CT, 06511, USA., Chen L; Immunobiology, Yale School of Medicine, New Haven, CT, 06511, USA., Herbst RS; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA., Schalper KA; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA. kurt.schalper@yale.edu.; Department of Pathology, Yale School of Medicine, New Haven, CT, 06511, USA. kurt.schalper@yale.edu.; Translational Immuno-oncology Laboratory, Yale Cancer Center, New Haven, CT, 06511, USA. kurt.schalper@yale.edu.
Source: Nature communications [Nat Commun] 2018 Aug 10; Vol. 9 (1), pp. 3196. Date of Electronic Publication: 2018 Aug 10.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Gettinger+SN%22">Gettinger SN</searchLink>; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Choi+J%22">Choi J</searchLink>; Department of Genetics, Yale School of Medicine, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Mani+N%22">Mani N</searchLink>; Department of Pathology, Yale School of Medicine, New Haven, CT, 06511, USA.; Translational Immuno-oncology Laboratory, Yale Cancer Center, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Sanmamed+MF%22">Sanmamed MF</searchLink>; Immunobiology, Yale School of Medicine, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Datar+I%22">Datar I</searchLink>; Department of Pathology, Yale School of Medicine, New Haven, CT, 06511, USA.; Translational Immuno-oncology Laboratory, Yale Cancer Center, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Sowell+R%22">Sowell R</searchLink>; Immunobiology, Yale School of Medicine, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Du+VY%22">Du VY</searchLink>; Immunobiology, Yale School of Medicine, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Kaftan+E%22">Kaftan E</searchLink>; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA.; Translational Immuno-oncology Laboratory, Yale Cancer Center, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Goldberg+S%22">Goldberg S</searchLink>; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Dong+W%22">Dong W</searchLink>; Department of Genetics, Yale School of Medicine, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Zelterman+D%22">Zelterman D</searchLink>; Yale School of Public Health, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Politi+K%22">Politi K</searchLink>; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA.; Department of Pathology, Yale School of Medicine, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Kavathas+P%22">Kavathas P</searchLink>; Immunobiology, Yale School of Medicine, New Haven, CT, 06511, USA.; Laboratory Medicine, Yale School of Medicine, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Kaech+S%22">Kaech S</searchLink>; Immunobiology, Yale School of Medicine, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Yu+X%22">Yu X</searchLink>; Yale School of Public Health, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Department of Genetics, Yale School of Medicine, New Haven, CT, 06511, USA.; Yale School of Public Health, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Schlessinger+J%22">Schlessinger J</searchLink>; Department of Pharmacology, Yale School of Medicine, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Lifton+R%22">Lifton R</searchLink>; Department of Genetics, Yale School of Medicine, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Rimm+DL%22">Rimm DL</searchLink>; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA.; Department of Pathology, Yale School of Medicine, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Immunobiology, Yale School of Medicine, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Herbst+RS%22">Herbst RS</searchLink>; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA.<br /><searchLink fieldCode="AU" term="%22Schalper+KA%22">Schalper KA</searchLink>; Medical Oncology and Yale Cancer Center, New Haven, CT, 06511, USA. kurt.schalper@yale.edu.; Department of Pathology, Yale School of Medicine, New Haven, CT, 06511, USA. kurt.schalper@yale.edu.; Translational Immuno-oncology Laboratory, Yale Cancer Center, New Haven, CT, 06511, USA. kurt.schalper@yale.edu.
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