Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.

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Title: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.
Authors: Bis JC; Department of Medicine (General Internal Medicine), University of Washington, Seattle, WA, USA., Jian X; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Kunkle BW; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Chen Y; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Hamilton-Nelson KL; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Bush WS; Case Western Reserve University, Cleveland Heights, OH, USA., Salerno WJ; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Lancour D; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Ma Y; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Renton AE; Department of Neuroscience and Ronald M Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Marcora E; Department of Neuroscience and Ronald M Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Farrell JJ; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Zhao Y; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Qu L; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Ahmad S; Erasmus University Medical Center, Rotterdam, Netherlands., Amin N; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France., Amouyel P; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Beecham GW; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Below JE; Department of Medical Genetics, Vanderbilt University Medical Center, Nashville, TN, USA., Campion D; Department of Genetics and CNR-MAJ, Normandie Université, UNIROUEN, Inserm U1245 and Rouen University Hospital, F 76000, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.; Department of Research, Centre Hospitalier du Rouvray, Sotteville-lès-, Rouen, France., Cantwell L; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Charbonnier C; Department of Genetics and CNR-MAJ, Normandie Université, UNIROUEN, Inserm U1245 and Rouen University Hospital, F 76000, Normandy Centre for Genomic and Personalized Medicine, Rouen, France., Chung J; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Crane PK; Department of Medicine (General Internal Medicine), University of Washington, Seattle, WA, USA., Cruchaga C; Department of Psychiatry, Washington University, St. Louis, MO, USA., Cupples LA; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA., Dartigues JF; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France., Debette S; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France.; Department of Neurology and Institute for Neurodegenerative Diseases, Bordeaux University Hospital, Memory Clinic, F-33000, Bordeaux, France., Deleuze JF; Centre National de Recherche en Génomique Humaine, Institut François Jacob, Direction de le Recherche Fondamentale, CEA, Evry, France., Fulton L; McDonnell Genome Institute, Washington University, St. Louis, MO, USA., Gabriel SB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Genin E; Inserm UMR-1078, CHRU Brest, Université Brest, Brest, France., Gibbs RA; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Goate A; Department of Neuroscience and Ronald M Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Grenier-Boley B; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France., Gupta N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Haines JL; Case Western Reserve University, Cleveland Heights, OH, USA., Havulinna AS; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; National Institute for Health and Welfare, Helsinki, Finland., Helisalmi S; Institute of Clinical Medicine - Neurology and Department of Neurology, University of Eastern Finland, Kuopio, Finland., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Howrigan DP; Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Ikram MA; Erasmus University Medical Center, Rotterdam, Netherlands., Kaprio J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Konrad J; Department of Psychiatry, Washington University, St. Louis, MO, USA., Kuzma A; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lathrop M; McGill University and Génome Québec Innovation Centre, Montréal, Canada., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland., Lin H; Department of Medicine (Computational Biomedicine), Boston University School of Medicine, Boston, MA, USA., Mattila K; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland., Mayeux R; Columbia University, New York, NY, USA., Muzny DM; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Nasser W; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Neale B; Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Nho K; Indiana University School of Medicine, Indianapolis, IN, USA., Nicolas G; Department of Genetics and CNR-MAJ, Normandie Université, UNIROUEN, Inserm U1245 and Rouen University Hospital, F 76000, Normandy Centre for Genomic and Personalized Medicine, Rouen, France., Patel D; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Perola M; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; National Institute for Health and Welfare, Helsinki, Finland.; University of Tartu, Estonian Genome Center, Tartu, Estonia., Psaty BM; Department of Medicine (General Internal Medicine), University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Quenez O; Department of Genetics and CNR-MAJ, Normandie Université, UNIROUEN, Inserm U1245 and Rouen University Hospital, F 76000, Normandy Centre for Genomic and Personalized Medicine, Rouen, France., Rajabli F; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Redon R; Inserm, CNRS, Univ. Nantes, CHU Nantes, l'institut du thorax, Nantes, France., Reitz C; Columbia University, New York, NY, USA., Remes AM; Institute of Clinical Medicine - Neurology and Department of Neurology, University of Eastern Finland, Kuopio, Finland.; Unit of Clinical Neuroscience, Neurology, University of Oulu and Medical Research Center, Oulu University Hospital, Oulu, Finland., Salomaa V; National Institute for Health and Welfare, Helsinki, Finland., Sarnowski C; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Schmidt H; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria., Schmidt M; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Schmidt R; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria., Soininen H; Institute of Clinical Medicine - Neurology and Department of Neurology, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Thornton TA; Department of Statistics, University of Washington, Seattle, WA, USA., Tosto G; Columbia University, New York, NY, USA., Tzourio C; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France., van der Lee SJ; Erasmus University Medical Center, Rotterdam, Netherlands., van Duijn CM; Erasmus University Medical Center, Rotterdam, Netherlands., Valladares O; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Vardarajan B; Columbia University, New York, NY, USA., Wang LS; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Wang W; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Wijsman E; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Wilson RK; McDonnell Genome Institute, Washington University, St. Louis, MO, USA., Witten D; Department of Statistics, University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Worley KC; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Zhang X; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Bellenguez C; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France., Lambert JC; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France., Kurki MI; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Daly M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Boerwinkle E; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Lunetta KL; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Destefano AL; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Departments of Neurology, Boston University School of Medicine, Boston, MA, USA., Dupuis J; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Martin ER; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Schellenberg GD; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Seshadri S; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Departments of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Naj AC; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Fornage M; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Farrer LA; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA. farrer@bu.Edu.; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. farrer@bu.Edu.; Departments of Neurology, Boston University School of Medicine, Boston, MA, USA. farrer@bu.Edu.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. farrer@bu.Edu.; Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA. farrer@bu.Edu.
Corporate Authors: Alzheimer’s Disease Sequencing Project
Source: Molecular psychiatry [Mol Psychiatry] 2020 Aug; Vol. 25 (8), pp. 1859-1875. Date of Electronic Publication: 2018 Aug 14.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-018-0112-7