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Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.

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Title: Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.
Authors: Pettersson M; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705., Johnson DS; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705., Rankic DA; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354., Kauffman GW; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705., Am Ende CW; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354., Butler TW; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354., Boscoe B; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354., Evrard E; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705., Helal CJ; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354., Humphrey JM; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354., Stepan AF; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705., Stiff CM; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354., Yang E; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354., Xie L; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354., Bales KR; Neuroscience and Pain Research Unit , Cambridge , Massachusetts 02139 , USA., Hajos-Korcsok E; Neuroscience and Pain Research Unit , Cambridge , Massachusetts 02139 , USA., Jenkinson S; Global Safety Pharmacology , Pfizer Worldwide Research and Development , La Jolla , California 92121 , USA., Pettersen B; Drug Safety R&D , Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , USA., Pustilnik LR; Primary Pharmacology Group , Groton , Connecticut 06340 , USA., Ramirez DS; Global Safety Pharmacology , Pfizer Worldwide Research and Development , La Jolla , California 92121 , USA., Steyn SJ; Pharmacokinetics, Dynamics and Metabolism , Pfizer Worldwide Research and Development , Cambridge , Massachusetts 02139 , USA., Wood KM; Neuroscience and Pain Research Unit , Cambridge , Massachusetts 02139 , USA., Verhoest PR; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705.
Source: MedChemComm [Medchemcomm] 2016 Nov 02; Vol. 8 (4), pp. 730-743. Date of Electronic Publication: 2016 Nov 02 (Print Publication: 2017).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101531525 Publication Model: eCollection Cited Medium: Print ISSN: 2040-2503 (Print) Linking ISSN: 20402503 NLM ISO Abbreviation: Medchemcomm Subsets: PubMed not MEDLINE
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  Data: Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Pettersson+M%22">Pettersson M</searchLink>; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705.<br /><searchLink fieldCode="AU" term="%22Johnson+DS%22">Johnson DS</searchLink>; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705.<br /><searchLink fieldCode="AU" term="%22Rankic+DA%22">Rankic DA</searchLink>; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.<br /><searchLink fieldCode="AU" term="%22Kauffman+GW%22">Kauffman GW</searchLink>; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705.<br /><searchLink fieldCode="AU" term="%22Am+Ende+CW%22">Am Ende CW</searchLink>; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.<br /><searchLink fieldCode="AU" term="%22Butler+TW%22">Butler TW</searchLink>; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.<br /><searchLink fieldCode="AU" term="%22Boscoe+B%22">Boscoe B</searchLink>; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.<br /><searchLink fieldCode="AU" term="%22Evrard+E%22">Evrard E</searchLink>; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705.<br /><searchLink fieldCode="AU" term="%22Helal+CJ%22">Helal CJ</searchLink>; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.<br /><searchLink fieldCode="AU" term="%22Humphrey+JM%22">Humphrey JM</searchLink>; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.<br /><searchLink fieldCode="AU" term="%22Stepan+AF%22">Stepan AF</searchLink>; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705.<br /><searchLink fieldCode="AU" term="%22Stiff+CM%22">Stiff CM</searchLink>; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.<br /><searchLink fieldCode="AU" term="%22Yang+E%22">Yang E</searchLink>; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.<br /><searchLink fieldCode="AU" term="%22Xie+L%22">Xie L</searchLink>; Neuroscience and Pain Medicinal Chemistry , Groton , Connecticut 06340 , USA . Email: danica.rankic@pfizer.com ; Tel: +(860) 441 4354.<br /><searchLink fieldCode="AU" term="%22Bales+KR%22">Bales KR</searchLink>; Neuroscience and Pain Research Unit , Cambridge , Massachusetts 02139 , USA.<br /><searchLink fieldCode="AU" term="%22Hajos-Korcsok+E%22">Hajos-Korcsok E</searchLink>; Neuroscience and Pain Research Unit , Cambridge , Massachusetts 02139 , USA.<br /><searchLink fieldCode="AU" term="%22Jenkinson+S%22">Jenkinson S</searchLink>; Global Safety Pharmacology , Pfizer Worldwide Research and Development , La Jolla , California 92121 , USA.<br /><searchLink fieldCode="AU" term="%22Pettersen+B%22">Pettersen B</searchLink>; Drug Safety R&D , Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , USA.<br /><searchLink fieldCode="AU" term="%22Pustilnik+LR%22">Pustilnik LR</searchLink>; Primary Pharmacology Group , Groton , Connecticut 06340 , USA.<br /><searchLink fieldCode="AU" term="%22Ramirez+DS%22">Ramirez DS</searchLink>; Global Safety Pharmacology , Pfizer Worldwide Research and Development , La Jolla , California 92121 , USA.<br /><searchLink fieldCode="AU" term="%22Steyn+SJ%22">Steyn SJ</searchLink>; Pharmacokinetics, Dynamics and Metabolism , Pfizer Worldwide Research and Development , Cambridge , Massachusetts 02139 , USA.<br /><searchLink fieldCode="AU" term="%22Wood+KM%22">Wood KM</searchLink>; Neuroscience and Pain Research Unit , Cambridge , Massachusetts 02139 , USA.<br /><searchLink fieldCode="AU" term="%22Verhoest+PR%22">Verhoest PR</searchLink>; Neuroscience and Pain Medicinal Chemistry , Cambridge , Massachusetts 02139 , USA . Email: martin.pettersson@pfizer.com ; Tel: +(617) 395 0705.
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