Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position.

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Title: Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position.
Authors: Cousin D; Pharminox Ltd , Biocity , Pennyfoot St. , Nottingham NG1 1GF , UK., Hummersone MG; Pharminox Ltd , Biocity , Pennyfoot St. , Nottingham NG1 1GF , UK., Bradshaw TD; School of Pharmacy , University of Nottingham , NG7 2RD , UK . Email: tracey.bradshaw@nottingham.ac.uk ; Email: malcolm.stevens@nottingham.ac.uk., Zhang J; School of Pharmacy , University of Nottingham , NG7 2RD , UK . Email: tracey.bradshaw@nottingham.ac.uk ; Email: malcolm.stevens@nottingham.ac.uk., Moody CJ; School of Chemistry , University of Nottingham , NG7 2RD , UK . Email: c.j.moody@nottingham.ac.uk., Foreiter MB; School of Chemistry , University of Nottingham , NG7 2RD , UK . Email: c.j.moody@nottingham.ac.uk., Summers HS; School of Chemistry , University of Nottingham , NG7 2RD , UK . Email: c.j.moody@nottingham.ac.uk., Lewis W; School of Chemistry , University of Nottingham , NG7 2RD , UK . Email: c.j.moody@nottingham.ac.uk., Wheelhouse RT; Institute of Cancer Therapeutics , School of Pharmacy and Medical Sciences , University of Bradford , Bradford , BD7 1DP , UK., Stevens MFG; School of Pharmacy , University of Nottingham , NG7 2RD , UK . Email: tracey.bradshaw@nottingham.ac.uk ; Email: malcolm.stevens@nottingham.ac.uk.
Source: MedChemComm [Medchemcomm] 2018 Jan 19; Vol. 9 (3), pp. 545-553. Date of Electronic Publication: 2018 Jan 19 (Print Publication: 2018).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101531525 Publication Model: eCollection Cited Medium: Print ISSN: 2040-2503 (Print) Linking ISSN: 20402503 NLM ISO Abbreviation: Medchemcomm Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2040-2503
DOI:10.1039/c7md00554g