Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.
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| Title: | Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors. |
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| Authors: | Anderson ND; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., de Borja R; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Young MD; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK., Fuligni F; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Rosic A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Roberts ND; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK., Hajjar S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Layeghifard M; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Novokmet A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Kowalski PE; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Anaka M; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Davidson S; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Zarrei M; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada., Id Said B; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Schreiner LC; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Marchand R; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Sitter J; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Gokgoz N; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Brunga L; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Graham GT; Department of Oncology and Pediatrics, Georgetown University, Washington, DC, USA., Fullam A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK., Pillay N; University College London Cancer Institute, Huntley Street, London, UK.; Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK., Toretsky JA; Department of Oncology and Pediatrics, Georgetown University, Washington, DC, USA., Yoshida A; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan., Shibata T; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.; Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Sciences, The University of Tokyo, Minato-ku, Tokyo, Japan., Metzler M; Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany., Somers GR; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Department of Pathology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Scherer SW; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; The McLaughlin Centre, University of Toronto, Toronto, Ontario, Canada., Flanagan AM; Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK.; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan., Campbell PJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Schiffman JD; Departments of Pediatrics and Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Shago M; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Alexandrov LB; Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, La Jolla, San Diego, CA, USA., Wunder JS; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada.; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada., Andrulis IL; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Malkin D; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. adam.shlien@sickkids.ca sb31@sanger.ac.uk david.malkin@sickkids.ca.; Division of Hematology-Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Pediatrics, University of Toronto, Ontario, Canada., Behjati S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. adam.shlien@sickkids.ca sb31@sanger.ac.uk david.malkin@sickkids.ca.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Shlien A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. adam.shlien@sickkids.ca sb31@sanger.ac.uk david.malkin@sickkids.ca.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. |
| Source: | Science (New York, N.Y.) [Science] 2018 Aug 31; Vol. 361 (6405). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.aam8419 |
