The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.
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| Title: | The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils. |
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| Authors: | D'Cruz AA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Speir M; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Bliss-Moreau M; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Dietrich S; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Wang S; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Chen AA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Gavillet M; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.; Department of Hematology, Lausanne University Hospital, 1011 Lausanne, Switzerland., Al-Obeidi A; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Lawlor KE; Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville 3052, Australia., Vince JE; Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville 3052, Australia., Kelliher MA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA., Hakem R; Ontario Cancer Institute, University Health Network, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada., Pasparakis M; Institute for Genetics, Center for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50931 Cologne, Germany., Williams DA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Ericsson M; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Croker BA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA. ben.croker@childrens.harvard.edu.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. |
| Source: | Science signaling [Sci Signal] 2018 Sep 04; Vol. 11 (546). Date of Electronic Publication: 2018 Sep 04. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1937-9145 |
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| DOI: | 10.1126/scisignal.aao1716 |
