Improved recovery of human islets from young donor pancreases utilizing increased protease dose to collagenase for digesting peri-islet extracellular matrix.

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Title: Improved recovery of human islets from young donor pancreases utilizing increased protease dose to collagenase for digesting peri-islet extracellular matrix.
Authors: Loganathan G; Clinical Islet Laboratory, Department of Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA., Subhashree V; School of Biosciences and Technology, VIT University, Vellore, TN, India., Narayanan S; Clinical Islet Laboratory, Department of Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA., Tweed B; Clinical Islet Laboratory, Department of Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA., Goedde MA; Clinical Islet Laboratory, Department of Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA., Gunaratnam B; Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA., Tucker WW; Clinical Islet Laboratory, Department of Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA., Goli P; Clinical Islet Laboratory, Department of Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA., Mokshagundam S; Department of Endocrinology, University of Louisville, Louisville, KY, USA., McCarthy RC; VitaCyte LLC, Indianapolis, IN, USA., Williams SK; Clinical Islet Laboratory, Department of Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.; Department of Physiology, University of Louisville, Louisville, KY, USA., Hughes MG; Clinical Islet Laboratory, Department of Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA., Balamurugan AN; Clinical Islet Laboratory, Department of Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.
Source: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2019 Mar; Vol. 19 (3), pp. 831-843. Date of Electronic Publication: 2018 Oct 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1600-6143
DOI:10.1111/ajt.15111