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Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors.

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Title: Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors.
Authors: Stefaniak J; Structural Genomics Consortium, Nuffield Department of Medicine , University of Oxford , Oxford , United Kingdom.; Target Discovery Institute, Nuffield Department of Medicine , University of Oxford , Oxford , United Kingdom.; Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Oxford , United Kingdom., Lewis AM; Structural Genomics Consortium, Nuffield Department of Medicine , University of Oxford , Oxford , United Kingdom.; Target Discovery Institute, Nuffield Department of Medicine , University of Oxford , Oxford , United Kingdom., Conole D; Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Oxford , United Kingdom., Galan SRG; Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Oxford , United Kingdom., Bataille CJR; Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Oxford , United Kingdom., Wynne GM; Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Oxford , United Kingdom.; Department of Pharmacology , University of Oxford , Oxford , United Kingdom., Castaldi MP; Discovery Sciences, IMED Biotech Unit , AstraZeneca , Waltham , Massachusetts 02451 , United States., Lundbäck T; Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gothenburg , Sweden., Russell AJ; Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Oxford , United Kingdom.; Department of Pharmacology , University of Oxford , Oxford , United Kingdom., Huber KVM; Structural Genomics Consortium, Nuffield Department of Medicine , University of Oxford , Oxford , United Kingdom.; Target Discovery Institute, Nuffield Department of Medicine , University of Oxford , Oxford , United Kingdom.
Source: ACS chemical biology [ACS Chem Biol] 2018 Oct 19; Vol. 13 (10), pp. 2849-2854. Date of Electronic Publication: 2018 Sep 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE
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  Data: Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Stefaniak+J%22">Stefaniak J</searchLink>; Structural Genomics Consortium, Nuffield Department of Medicine , University of Oxford , Oxford , United Kingdom.; Target Discovery Institute, Nuffield Department of Medicine , University of Oxford , Oxford , United Kingdom.; Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Oxford , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lewis+AM%22">Lewis AM</searchLink>; Structural Genomics Consortium, Nuffield Department of Medicine , University of Oxford , Oxford , United Kingdom.; Target Discovery Institute, Nuffield Department of Medicine , University of Oxford , Oxford , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Conole+D%22">Conole D</searchLink>; Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Oxford , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Galan+SRG%22">Galan SRG</searchLink>; Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Oxford , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bataille+CJR%22">Bataille CJR</searchLink>; Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Oxford , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wynne+GM%22">Wynne GM</searchLink>; Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Oxford , United Kingdom.; Department of Pharmacology , University of Oxford , Oxford , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Castaldi+MP%22">Castaldi MP</searchLink>; Discovery Sciences, IMED Biotech Unit , AstraZeneca , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Lundbäck+T%22">Lundbäck T</searchLink>; Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gothenburg , Sweden.<br /><searchLink fieldCode="AU" term="%22Russell+AJ%22">Russell AJ</searchLink>; Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Oxford , United Kingdom.; Department of Pharmacology , University of Oxford , Oxford , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Huber+KVM%22">Huber KVM</searchLink>; Structural Genomics Consortium, Nuffield Department of Medicine , University of Oxford , Oxford , United Kingdom.; Target Discovery Institute, Nuffield Department of Medicine , University of Oxford , Oxford , United Kingdom.
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  Data: <searchLink fieldCode="JN" term="%22101282906%22">ACS chemical biology</searchLink> [ACS Chem Biol] 2018 Oct 19; Vol. 13 (10), pp. 2849-2854. <i>Date of Electronic Publication: </i>2018 Sep 19.
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              Text: 2018 Oct 19
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