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Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.

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Title: Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.
Authors: Gammage PA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. payam.gammage@mrc-mbu.cam.ac.uk., Viscomi C; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Simard ML; Max Planck Institute for Biology of Ageing, Cologne, Germany., Costa ASH; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Gaude E; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Powell CA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Van Haute L; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., McCann BJ; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Rebelo-Guiomar P; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Graduate Program in Areas of Basic and Applied Biology (GABBA), University of Porto, Porto, Portugal., Cerutti R; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Zhang L; Sangamo Therapeutics Inc., Richmond, CA, USA., Rebar EJ; Sangamo Therapeutics Inc., Richmond, CA, USA., Zeviani M; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Frezza C; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Stewart JB; Max Planck Institute for Biology of Ageing, Cologne, Germany., Minczuk M; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. michal.minczuk@mrc-mbu.cam.ac.uk.
Source: Nature medicine [Nat Med] 2018 Nov; Vol. 24 (11), pp. 1691-1695. Date of Electronic Publication: 2018 Sep 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Gammage+PA%22">Gammage PA</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. payam.gammage@mrc-mbu.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Viscomi+C%22">Viscomi C</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Simard+ML%22">Simard ML</searchLink>; Max Planck Institute for Biology of Ageing, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Costa+ASH%22">Costa ASH</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gaude+E%22">Gaude E</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Powell+CA%22">Powell CA</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Van+Haute+L%22">Van Haute L</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22McCann+BJ%22">McCann BJ</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rebelo-Guiomar+P%22">Rebelo-Guiomar P</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Graduate Program in Areas of Basic and Applied Biology (GABBA), University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Cerutti+R%22">Cerutti R</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Sangamo Therapeutics Inc., Richmond, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rebar+EJ%22">Rebar EJ</searchLink>; Sangamo Therapeutics Inc., Richmond, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zeviani+M%22">Zeviani M</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Frezza+C%22">Frezza C</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Stewart+JB%22">Stewart JB</searchLink>; Max Planck Institute for Biology of Ageing, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Minczuk+M%22">Minczuk M</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. michal.minczuk@mrc-mbu.cam.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2018 Nov; Vol. 24 (11), pp. 1691-1695. <i>Date of Electronic Publication: </i>2018 Sep 24.
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