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Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety.

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Title: Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety.
Authors: Van der Jeught K; Laboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences , Vrije Universiteit Brussel (VUB) , Brussels 1090 , Belgium., De Koker S; eTheRNA Immunotherapies NV , Niel 2845 , Belgium., Bialkowski L; Laboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences , Vrije Universiteit Brussel (VUB) , Brussels 1090 , Belgium., Heirman C; Laboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences , Vrije Universiteit Brussel (VUB) , Brussels 1090 , Belgium., Tjok Joe P; Laboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences , Vrije Universiteit Brussel (VUB) , Brussels 1090 , Belgium., Perche F; Centre de Biophysique Moléculaire, CNRS UPR 4301, University and Inserm , Orléans 45071 , France., Maenhout S; eTheRNA Immunotherapies NV , Niel 2845 , Belgium., Bevers S; eTheRNA Immunotherapies NV , Niel 2845 , Belgium., Broos K; Laboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences , Vrije Universiteit Brussel (VUB) , Brussels 1090 , Belgium., Deswarte K; VIB Inflammation Research Center , UGent , Ghent 9052 , Belgium., Malard V; Centre de Biophysique Moléculaire, CNRS UPR 4301, University and Inserm , Orléans 45071 , France., Hammad H; VIB Inflammation Research Center , UGent , Ghent 9052 , Belgium., Baril P; Centre de Biophysique Moléculaire, CNRS UPR 4301, University and Inserm , Orléans 45071 , France., Benvegnu T; Ecole Nationale Supérieure de Chimie de Rennes, CNRS UMR6226 , Rennes 35708 , France., Jaffrès PA; CEMA, CNRS UMR 6521, SFR148 ScInBioS , Université de Brest , Brest 29238 , France., Kooijmans SAA; University Medical Center Utrecht, Universiteit Utrecht , Utrecht 3584 , Netherlands., Schiffelers R; University Medical Center Utrecht, Universiteit Utrecht , Utrecht 3584 , Netherlands., Lienenklaus S; Hannover Medical School , Hannover 30625 , Germany., Midoux P; Centre de Biophysique Moléculaire, CNRS UPR 4301, University and Inserm , Orléans 45071 , France., Pichon C; Centre de Biophysique Moléculaire, CNRS UPR 4301, University and Inserm , Orléans 45071 , France., Breckpot K; Laboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences , Vrije Universiteit Brussel (VUB) , Brussels 1090 , Belgium., Thielemans K; Laboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences , Vrije Universiteit Brussel (VUB) , Brussels 1090 , Belgium.
Source: ACS nano [ACS Nano] 2018 Oct 23; Vol. 12 (10), pp. 9815-9829. Date of Electronic Publication: 2018 Oct 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1936-086X
DOI:10.1021/acsnano.8b00966