Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.
Saved in:
| Title: | Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. |
|---|---|
| Authors: | Mahajan A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. anubha@well.ox.ac.uk.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. anubha@well.ox.ac.uk., Taliun D; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Thurner M; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Robertson NR; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Torres JM; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Rayner NW; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Payne AJ; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Steinthorsdottir V; deCODE Genetics, Amgen Inc., Reykjavik, Iceland., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Cook JP; Department of Biostatistics, University of Liverpool, Liverpool, UK., Schmidt EM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Wuttke M; Institute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Sarnowski C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Nano J; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Trompet S; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Lecoeur C; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France., Preuss MH; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Prins BP; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Guo X; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Below JE; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Bowden DW; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK., Kim YJ; Division of Genome Research, Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Republic of Korea., Ng MCY; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Petty LE; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Sim X; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UK., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brummett CM; Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA., Canouil M; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France., Ec Kardt KU; Department of Nephrology and Medical Intensive Care and German Chronic Kidney Disease Study, Charité, Universitätsmedizin Berlin, Berlin, Germany., Fischer K; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kronenberg F; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Läll K; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Locke AE; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.; Division of Genomics & Bioinformatics, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Ntalla I; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Nylander V; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Schönherr S; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Schurmann C; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Yengo L; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France., Bottinger EP; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Brandslund I; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark., Christensen C; Medical Department, Lillebælt Hospital Vejle, Vejle, Denmark., Dedoussis G; Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece., Florez JC; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Hackinger S; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter, UK., Herder C; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Ikram MA; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Ingelsson M; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Jørgensen ME; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; National Institute of Public Health, Southern Denmark University, Copenhagen, Denmark., Jørgensen T; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Medicine, Aalborg University, Aalborg, Denmark., Kriebel J; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Ligthart S; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Lindgren CM; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Big Data Institute, Li Ka Shing Centre For Health Information and Discovery, University of Oxford, Oxford, UK., Linneberg A; Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway., Mamakou V; Dromokaiteio Psychiatric Hospital, National and Kapodistrian University of Athens, Athens, Greece., Meitinger T; Institute of Human Genetics, Technische Universität München, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance partner site, Munich, Germany., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Morris AD; Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, UK.; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Nadkarni G; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Peters A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance partner site, Munich, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Stančáková A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany., Taylor KD; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Thorand B; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Thorleifsson G; deCODE Genetics, Amgen Inc., Reykjavik, Iceland., Thorsteinsdottir U; deCODE Genetics, Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tuomilehto J; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Dasman Diabetes Institute, Dasman, Kuwait.; Department of Neuroscience and Preventive Medicine, Danube-University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Witte DR; Department of Public Health, Aarhus University, Aarhus, Denmark.; Danish Diabetes Academy, Odense, Denmark., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Zeggini E; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Froguel P; CNRS-UMR8199, Lille University, Lille Pasteur Institute, Lille, France.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Ingelsson E; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Groop L; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Finnish Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Collins FS; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Clinical Cooparation Group Type 2 Diabetes, Helmholtz Zentrum München, Ludwig-Maximilians-Universität, Munich, Germany.; Clinical Cooparation Group Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum München, Technical University, Munich, Germany., Metspalu A; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Dehghan A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK., Köttgen A; Institute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Abecasis GR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Meigs JB; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Rotter JI; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.; Departments of Medicine, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Marchini J; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Stefansson K; deCODE Genetics, Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Gloyn AL; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Morris AP; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. mark.mccarthy@drl.ox.ac.uk.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. mark.mccarthy@drl.ox.ac.uk.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK. mark.mccarthy@drl.ox.ac.uk. |
| Source: | Nature genetics [Nat Genet] 2018 Nov; Vol. 50 (11), pp. 1505-1513. Date of Electronic Publication: 2018 Oct 08. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
Be the first to leave a comment!
