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Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.

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Bibliographic Details
Title: Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.
Authors: McCoull W; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Cheung T; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Anderson E; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Barton P; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Burgess J; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Byth K; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Cao Q; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Castaldi MP; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Chen H; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Chiarparin E; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Carbajo RJ; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Code E; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Cowan S; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Davey PR; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Ferguson AD; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Fillery S; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Fuller NO; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Gao N; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Hargreaves D; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Howard MR; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Hu J; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Kawatkar A; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Kemmitt PD; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Leo E; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Molina DM; Pelago Bioscience AB , Banvaktsvägen 20 , 17148 Solna , Sweden., O'Connell N; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Petteruti P; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Rasmusson T; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Raubo P; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Rawlins PB; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Ricchiuto P; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Robb GR; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Schenone M; Broad Institute of Harvard and MIT , 7 Cambridge Center , Cambridge , Massachusetts 02142 , United States., Waring MJ; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K., Zinda M; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Fawell S; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gatehouse Park , Waltham , Massachusetts 02451 , United States., Wilson DM; Oncology and Discovery Sciences, IMED Biotech Unit , AstraZeneca , 310 Cambridge Science Park, Milton Road , Cambridge CB4 0WG , U.K.
Source: ACS chemical biology [ACS Chem Biol] 2018 Nov 16; Vol. 13 (11), pp. 3131-3141. Date of Electronic Publication: 2018 Oct 17.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1554-8937
DOI:10.1021/acschembio.8b00698