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Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors.

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Title: Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors.
Authors: Hu CH; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States. Electronic address: Carol.Hu@bms.com., Wang TC; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States. Electronic address: Tammy.Wang@bms.com., Qiao JX; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Haque L; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Chen AYA; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Taylor DS; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Ying X; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Onorato JM; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Galella M; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Shen H; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Huang CS; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Toussaint N; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Li YX; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Abell L; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Adam LP; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Gordon D; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Wexler RR; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States., Finlay HJ; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Dec 15; Vol. 28 (23-24), pp. 3721-3725. Date of Electronic Publication: 2018 Oct 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Hu+CH%22">Hu CH</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States. Electronic address: Carol.Hu@bms.com.<br /><searchLink fieldCode="AU" term="%22Wang+TC%22">Wang TC</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States. Electronic address: Tammy.Wang@bms.com.<br /><searchLink fieldCode="AU" term="%22Qiao+JX%22">Qiao JX</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Haque+L%22">Haque L</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Chen+AYA%22">Chen AYA</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Taylor+DS%22">Taylor DS</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Ying+X%22">Ying X</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Onorato+JM%22">Onorato JM</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Galella+M%22">Galella M</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Shen+H%22">Shen H</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Huang+CS%22">Huang CS</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Toussaint+N%22">Toussaint N</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Li+YX%22">Li YX</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Abell+L%22">Abell L</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Adam+LP%22">Adam LP</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Gordon+D%22">Gordon D</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Wexler+RR%22">Wexler RR</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.<br /><searchLink fieldCode="AU" term="%22Finlay+HJ%22">Finlay HJ</searchLink>; Research and Development, Bristol-Myers Squibb, Princeton, NJ 08543, United States.
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2018 Dec 15; Vol. 28 (23-24), pp. 3721-3725. <i>Date of Electronic Publication: </i>2018 Oct 15.
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