Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis.
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| Title: | Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. |
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| Authors: | Scott NA; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, UK.; Manchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK., Andrusaite A; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Andersen P; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Lawson M; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UA, UK., Alcon-Giner C; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UA, UK., Leclaire C; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UA, UK., Caim S; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UA, UK., Le Gall G; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UA, UK., Shaw T; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, UK.; Manchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK., Connolly JPR; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Roe AJ; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Wessel H; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Bravo-Blas A; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Thomson CA; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Kästele V; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Wang P; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, UK., Peterson DA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Eli Lilly and Company, Indianapolis, 46285 IN, USA., Bancroft A; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, UK.; Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK., Li X; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Grencis R; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, UK.; Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK., Mowat AM; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Hall LJ; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UA, UK., Travis MA; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, UK.; Manchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK.; Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK., Milling SWF; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Mann ER; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, UK. elizabeth.mann@manchester.ac.uk.; Manchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK.; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. |
| Source: | Science translational medicine [Sci Transl Med] 2018 Oct 24; Vol. 10 (464). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.aao4755 |
