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Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.

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Title: Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.
Authors: Kam TI; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, USA., Mao X; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, USA., Park H; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, USA., Chou SC; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Karuppagounder SS; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, USA., Umanah GE; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Yun SP; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, USA., Brahmachari S; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, USA., Panicker N; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, USA., Chen R; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, USA., Andrabi SA; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Qi C; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Xin Hua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China., Poirier GG; Centre de recherche du CHU de Québec-Pavillon CHUL, Faculté de Médecine, Université Laval, Québec G1V 4G2, Canada., Pletnikova O; Department of Pathology (Neuropathology), Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Troncoso JC; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Pathology (Neuropathology), Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Bekris LM; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH 44195, USA., Leverenz JB; Lou Ruvo Center for Brain Health, Neurological Institute, and Department of Neurology, Cleveland Clinic, Cleveland, OH 44195, USA., Pantelyat A; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Ko HS; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, USA., Rosenthal LS; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Dawson TM; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. tdawson@jhmi.edu vdawson1@jhmi.edu.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, USA.; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Dawson VL; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. tdawson@jhmi.edu vdawson1@jhmi.edu.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Source: Science (New York, N.Y.) [Science] 2018 Nov 02; Vol. 362 (6414).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1095-9203
DOI:10.1126/science.aat8407