Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles.

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Title: Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles.
Authors: Friedrich J; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Kordasiewicz HB; Ionis Pharmaceuticals, Carlsbad, California, USA., O'Callaghan B; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Handler HP; Institute for Translational Neuroscience and.; Graduate Program in Neuroscience., Wagener C; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Duvick L; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Swayze EE; Ionis Pharmaceuticals, Carlsbad, California, USA., Rainwater O; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Hofstra B; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Benneyworth M; Department of Neuroscience, and., Nichols-Meade T; Department of Neuroscience, and., Yang P; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Chen Z; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Ortiz JP; Institute for Translational Neuroscience and.; Graduate Program in Neuroscience., Clark HB; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Öz G; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA., Larson S; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA., Zoghbi HY; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, USA., Henzler C; Research Informatics Support Systems Bioinformatics, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota, USA., Orr HT; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
Source: JCI insight [JCI Insight] 2018 Nov 02; Vol. 3 (21). Date of Electronic Publication: 2018 Nov 02.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2379-3708
DOI:10.1172/jci.insight.123193