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Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles.

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Title: Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles.
Authors: Friedrich J; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Kordasiewicz HB; Ionis Pharmaceuticals, Carlsbad, California, USA., O'Callaghan B; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Handler HP; Institute for Translational Neuroscience and.; Graduate Program in Neuroscience., Wagener C; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Duvick L; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Swayze EE; Ionis Pharmaceuticals, Carlsbad, California, USA., Rainwater O; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Hofstra B; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Benneyworth M; Department of Neuroscience, and., Nichols-Meade T; Department of Neuroscience, and., Yang P; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Chen Z; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Ortiz JP; Institute for Translational Neuroscience and.; Graduate Program in Neuroscience., Clark HB; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Öz G; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA., Larson S; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA., Zoghbi HY; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, USA., Henzler C; Research Informatics Support Systems Bioinformatics, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota, USA., Orr HT; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
Source: JCI insight [JCI Insight] 2018 Nov 02; Vol. 3 (21). Date of Electronic Publication: 2018 Nov 02.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles.
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  Data: <searchLink fieldCode="AU" term="%22Friedrich+J%22">Friedrich J</searchLink>; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Kordasiewicz+HB%22">Kordasiewicz HB</searchLink>; Ionis Pharmaceuticals, Carlsbad, California, USA.<br /><searchLink fieldCode="AU" term="%22O'Callaghan+B%22">O'Callaghan B</searchLink>; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Handler+HP%22">Handler HP</searchLink>; Institute for Translational Neuroscience and.; Graduate Program in Neuroscience.<br /><searchLink fieldCode="AU" term="%22Wagener+C%22">Wagener C</searchLink>; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Duvick+L%22">Duvick L</searchLink>; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Swayze+EE%22">Swayze EE</searchLink>; Ionis Pharmaceuticals, Carlsbad, California, USA.<br /><searchLink fieldCode="AU" term="%22Rainwater+O%22">Rainwater O</searchLink>; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Hofstra+B%22">Hofstra B</searchLink>; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Benneyworth+M%22">Benneyworth M</searchLink>; Department of Neuroscience, and.<br /><searchLink fieldCode="AU" term="%22Nichols-Meade+T%22">Nichols-Meade T</searchLink>; Department of Neuroscience, and.<br /><searchLink fieldCode="AU" term="%22Yang+P%22">Yang P</searchLink>; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Ortiz+JP%22">Ortiz JP</searchLink>; Institute for Translational Neuroscience and.; Graduate Program in Neuroscience.<br /><searchLink fieldCode="AU" term="%22Clark+HB%22">Clark HB</searchLink>; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Öz+G%22">Öz G</searchLink>; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Larson+S%22">Larson S</searchLink>; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Zoghbi+HY%22">Zoghbi HY</searchLink>; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Henzler+C%22">Henzler C</searchLink>; Research Informatics Support Systems Bioinformatics, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Orr+HT%22">Orr HT</searchLink>; Institute for Translational Neuroscience and.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2018 Nov 02; Vol. 3 (21). <i>Date of Electronic Publication: </i>2018 Nov 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101676073 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2379-3708 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223793708%22">23793708 </searchLink><i>NLM ISO Abbreviation: </i>JCI Insight <i>Subsets: </i>MEDLINE
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