A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity.
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| Title: | A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity. |
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| Authors: | Compte M; Department of Antibody Engineering, Leadartis SL, 28008, Madrid, Spain., Harwood SL; Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, 8000C, Aarhus, Denmark., Muñoz IG; Crystallography and Protein Engineering Unit, Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain., Navarro R; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain., Zonca M; Department of Antibody Engineering, Leadartis SL, 28008, Madrid, Spain., Perez-Chacon G; Instituto de Investigaciones Biomédicas Alberto Sols (IIBm), CSIC-UAM, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), 28029, Madrid, Spain., Erce-Llamazares A; Department of Antibody Engineering, Leadartis SL, 28008, Madrid, Spain., Merino N; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Bizkaia, 48160, Derio, Spain., Tapia-Galisteo A; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain., Cuesta AM; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain., Mikkelsen K; Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, 8000C, Aarhus, Denmark., Caleiras E; Histopathology Unit, Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain., Nuñez-Prado N; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain., Aznar MA; Department of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain., Lykkemark S; Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, 8000C, Aarhus, Denmark., Martínez-Torrecuadrada J; Crystallography and Protein Engineering Unit, Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain., Melero I; Department of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.; Department of Immunology, University Clinic, University of Navarra, 31008 Pamplona, Spain.; Instituto de Investigación Sanitaria de Navarra (IdISNA), 31008 Pamplona, Spain.; CIBERONC-Centro virtual de Investigación Biomédica en red de Oncología, 28029 Madrid, Spain., Blanco FJ; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Bizkaia, 48160, Derio, Spain.; IKERBASQUE, Basque Foundation for Science, 48013, Bilbao, Spain., Bernardino de la Serna J; Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Research Complex at Harwell, OX11 0QX Harwell-Oxford, UK.; Department of Physics, King's College London, WC2R 2LS London, UK., Zapata JM; Instituto de Investigaciones Biomédicas Alberto Sols (IIBm), CSIC-UAM, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), 28029, Madrid, Spain., Sanz L; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain., Alvarez-Vallina L; Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, 8000C, Aarhus, Denmark. lav@eng.au.dk.; Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, 28041, Madrid, Spain. lav@eng.au.dk.; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (i+12), 28041, Madrid, Spain. lav@eng.au.dk. |
| Source: | Nature communications [Nat Commun] 2018 Nov 15; Vol. 9 (1), pp. 4809. Date of Electronic Publication: 2018 Nov 15. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-018-07195-w |
