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Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.

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Title: Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.
Authors: Choi SH; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Weng LC; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Cardiovascular Research Center, Massachusetts General Hospital, Boston., Roselli C; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Lin H; National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, Massachusetts.; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts., Haggerty CM; Department of Imaging Science and Innovation, Geisinger, Danville, Pennsylvania., Shoemaker MB; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Barnard J; Departments of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio., Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Chasman DI; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Divisions of Preventive Medicine and Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Albert CM; Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Chaffin M; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Tucker NR; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Cardiovascular Research Center, Massachusetts General Hospital, Boston., Smith JD; Departments of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio., Gupta N; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Gabriel S; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Margolin L; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Shea MA; Cardiovascular Research Center, Massachusetts General Hospital, Boston., Shaffer CM; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Yoneda ZT; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston., Smith NL; Department of Epidemiology and Cardiovascular Health Research Unit, University of Washington, Seattle., Silverman EK; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Redline S; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts., Vasan RS; National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, Massachusetts., Burchard EG; Department of Bioengineering, School of Pharmacy, University of California, San Francisco., Gogarten SM; Department of Biostatistics, University of Washington, Seattle., Laurie C; Department of Biostatistics, University of Washington, Seattle., Blackwell TW; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor., Abecasis G; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor., Carey DJ; Department of Molecular and Functional Genomics, Geisinger, Danville, Pennsylvania., Fornwalt BK; Department of Imaging Science and Innovation, Geisinger, Danville, Pennsylvania., Smelser DT; Department of Molecular and Functional Genomics, Geisinger, Danville, Pennsylvania., Baras A; Regeneron Genetics Center, Tarrytown, New York., Dewey FE; Regeneron Genetics Center, Tarrytown, New York., Jaquish CE; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Papanicolaou GJ; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Sotoodehnia N; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle., Van Wagoner DR; Departments of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio., Psaty BM; Department of Epidemiology and Cardiovascular Health Research Unit, University of Washington, Seattle.; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle.; Kaiser Permanente Washington Health Research Institute, Seattle, Washington.; Department of Health Services, University of Washington, Seattle., Kathiresan S; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Darbar D; Division of Cardiology, Department of Medicine, University of Illinois, Chicago., Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia., Heckbert SR; Department of Epidemiology and Cardiovascular Health Research Unit, University of Washington, Seattle.; Kaiser Permanente Washington Health Research Institute, Seattle, Washington., Chung MK; Departments of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio., Roden DM; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Benjamin EJ; National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, Massachusetts.; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts., Murray MF; Genomic Medicine Institute, Geisinger, Danville, Pennsylvania., Lunetta KL; National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, Massachusetts.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts., Lubitz SA; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Cardiovascular Research Center, Massachusetts General Hospital, Boston.; Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston., Ellinor PT; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Cardiovascular Research Center, Massachusetts General Hospital, Boston.; Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston.
Corporate Authors: DiscovEHR study and the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Source: JAMA [JAMA] 2018 Dec 11; Vol. 320 (22), pp. 2354-2364.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.
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