HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity.
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| Title: | HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity. |
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| Authors: | Zheng J; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, 33458, USA. jzheng@scripps.edu., Wang C; Structural Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Chang MR; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, 33458, USA., Devarkar SC; Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, 08854, USA., Schweibenz B; Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, 08854, USA., Crynen GC; The Center for Computational Biology, The Scripps Research Institute, Jupiter, FL, 33458, USA., Garcia-Ordonez RD; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, 33458, USA., Pascal BD; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, 33458, USA.; Omics Informatics LLC, Honolulu, HI 96813, USA., Novick SJ; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, 33458, USA., Patel SS; Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, 08854, USA., Marcotrigiano J; Structural Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA. joseph.marcotrigiano@nih.gov., Griffin PR; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, 33458, USA. pgriffin@scripps.edu. |
| Source: | Nature communications [Nat Commun] 2018 Dec 18; Vol. 9 (1), pp. 5366. Date of Electronic Publication: 2018 Dec 18. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-018-07780-z |
