Novel dual-action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine-specific histone demethylase 1A inhibitor.
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| Title: | Novel dual-action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine-specific histone demethylase 1A inhibitor. |
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| Authors: | Engel M; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia., Gee YS; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia., Cross D; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia., Maccarone A; Mass Spectrometry User Resource and Research Facility, School of Chemistry, University of Wollongong, Wollongong, New South Wales, Australia., Heng B; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia., Hulme A; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia., Smith G; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia., Guillemin GJ; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia., Stringer BW; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Hyland CJT; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia., Ooi L; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia. |
| Source: | Journal of neurochemistry [J Neurochem] 2019 May; Vol. 149 (4), pp. 535-550. Date of Electronic Publication: 2019 Feb 03. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1471-4159 |
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| DOI: | 10.1111/jnc.14655 |
