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Novel dual-action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine-specific histone demethylase 1A inhibitor.

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Title: Novel dual-action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine-specific histone demethylase 1A inhibitor.
Authors: Engel M; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia., Gee YS; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia., Cross D; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia., Maccarone A; Mass Spectrometry User Resource and Research Facility, School of Chemistry, University of Wollongong, Wollongong, New South Wales, Australia., Heng B; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia., Hulme A; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia., Smith G; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia., Guillemin GJ; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia., Stringer BW; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Hyland CJT; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia., Ooi L; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia.
Source: Journal of neurochemistry [J Neurochem] 2019 May; Vol. 149 (4), pp. 535-550. Date of Electronic Publication: 2019 Feb 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel dual-action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine-specific histone demethylase 1A inhibitor.
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  Data: <searchLink fieldCode="AU" term="%22Engel+M%22">Engel M</searchLink>; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Gee+YS%22">Gee YS</searchLink>; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Cross+D%22">Cross D</searchLink>; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Maccarone+A%22">Maccarone A</searchLink>; Mass Spectrometry User Resource and Research Facility, School of Chemistry, University of Wollongong, Wollongong, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Heng+B%22">Heng B</searchLink>; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Hulme+A%22">Hulme A</searchLink>; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Smith+G%22">Smith G</searchLink>; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Guillemin+GJ%22">Guillemin GJ</searchLink>; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Stringer+BW%22">Stringer BW</searchLink>; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Hyland+CJT%22">Hyland CJT</searchLink>; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Ooi+L%22">Ooi L</searchLink>; Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia.
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  Data: <searchLink fieldCode="JN" term="%222985190R%22">Journal of neurochemistry</searchLink> [J Neurochem] 2019 May; Vol. 149 (4), pp. 535-550. <i>Date of Electronic Publication: </i>2019 Feb 03.
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