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Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.

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Title: Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
Authors: Fell JB; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Fischer JP; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Baer BR; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Ballard J; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Blake JF; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Bouhana K; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Brandhuber BJ; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Briere DM; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States., Burgess LE; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Burkard MR; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Chiang H; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States., Chicarelli MJ; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Davidson K; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Gaudino JJ; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Hallin J; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States., Hanson L; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Hee K; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Hicken EJ; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Hinklin RJ; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Marx MA; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States., Mejia MJ; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Olson P; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States., Savechenkov P; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Sudhakar N; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States., Tang TP; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Vigers GP; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Zecca H; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States., Christensen JG; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Nov 07; Vol. 9 (12), pp. 1230-1234. Date of Electronic Publication: 2018 Nov 07 (Print Publication: 2018).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
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