Novel small molecule IL-6 inhibitor suppresses autoreactive Th17 development and promotes Treg development.
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| Title: | Novel small molecule IL-6 inhibitor suppresses autoreactive Th17 development and promotes T |
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| Authors: | Aqel SI; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Kraus EE; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Jena N; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Kumari V; Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Granitto MC; Neuroscience Program, College of Arts and Sciences, The Ohio State University, Columbus, OH, USA., Mao L; Department of Medicinal Chemistry, University of Florida, Gainsville, FL, USA., Farinas MF; Neuroscience Program, College of Arts and Sciences, The Ohio State University, Columbus, OH, USA., Zhao EY; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Perottino G; Neuroscience Program, College of Arts and Sciences, The Ohio State University, Columbus, OH, USA., Pei W; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Lovett-Racke AE; Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Racke MK; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Fuchs JR; Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Li C; Department of Medicinal Chemistry, University of Florida, Gainsville, FL, USA., Yang Y; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, USA. |
| Source: | Clinical and experimental immunology [Clin Exp Immunol] 2019 May; Vol. 196 (2), pp. 215-225. Date of Electronic Publication: 2019 Jan 24. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2249 (Electronic) Linking ISSN: 00099104 NLM ISO Abbreviation: Clin Exp Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1365-2249 |
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| DOI: | 10.1111/cei.13258 |
