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Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity.

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Title: Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity.
Authors: Botros SS; Pharmacology Department, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt., William S; Parasitology Department, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt., Sabra AA; Pharmacology Department, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt., El-Lakkany NM; Pharmacology Department, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt., Seif El-Din SH; Pharmacology Department, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt., García-Rubia A; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain., Sebastián-Pérez V; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain., Blaazer AR; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands., de Heuvel E; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands., Sijm M; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands., Zheng Y; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands., Salado IG; University of Antwerp (UA), Belgium., Munday JC; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK., Maes L; University of Antwerp (UA), Belgium., de Esch IJP; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands., Sterk GJ; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands., Augustyns K; University of Antwerp (UA), Belgium., Leurs R; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands., Gil C; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain., De Koning HP; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK. Electronic address: Harry.de-Koning@glasgow.ac.uk.
Source: International journal for parasitology. Drugs and drug resistance [Int J Parasitol Drugs Drug Resist] 2019 Apr; Vol. 9, pp. 35-43. Date of Electronic Publication: 2019 Jan 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101576715 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-3207 (Electronic) Linking ISSN: 22113207 NLM ISO Abbreviation: Int J Parasitol Drugs Drug Resist Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity.
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  Data: <searchLink fieldCode="AU" term="%22Botros+SS%22">Botros SS</searchLink>; Pharmacology Department, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt.<br /><searchLink fieldCode="AU" term="%22William+S%22">William S</searchLink>; Parasitology Department, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt.<br /><searchLink fieldCode="AU" term="%22Sabra+AA%22">Sabra AA</searchLink>; Pharmacology Department, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Lakkany+NM%22">El-Lakkany NM</searchLink>; Pharmacology Department, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt.<br /><searchLink fieldCode="AU" term="%22Seif+El-Din+SH%22">Seif El-Din SH</searchLink>; Pharmacology Department, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt.<br /><searchLink fieldCode="AU" term="%22García-Rubia+A%22">García-Rubia A</searchLink>; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sebastián-Pérez+V%22">Sebastián-Pérez V</searchLink>; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Blaazer+AR%22">Blaazer AR</searchLink>; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Heuvel+E%22">de Heuvel E</searchLink>; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sijm+M%22">Sijm M</searchLink>; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zheng+Y%22">Zheng Y</searchLink>; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands.<br /><searchLink fieldCode="AU" term="%22Salado+IG%22">Salado IG</searchLink>; University of Antwerp (UA), Belgium.<br /><searchLink fieldCode="AU" term="%22Munday+JC%22">Munday JC</searchLink>; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.<br /><searchLink fieldCode="AU" term="%22Maes+L%22">Maes L</searchLink>; University of Antwerp (UA), Belgium.<br /><searchLink fieldCode="AU" term="%22de+Esch+IJP%22">de Esch IJP</searchLink>; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sterk+GJ%22">Sterk GJ</searchLink>; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands.<br /><searchLink fieldCode="AU" term="%22Augustyns+K%22">Augustyns K</searchLink>; University of Antwerp (UA), Belgium.<br /><searchLink fieldCode="AU" term="%22Leurs+R%22">Leurs R</searchLink>; Medicinal Chemistry Vrije Universiteit Amsterdam (VUA), the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gil+C%22">Gil C</searchLink>; Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22De+Koning+HP%22">De Koning HP</searchLink>; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK. Electronic address: Harry.de-Koning@glasgow.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101576715%22">International journal for parasitology. Drugs and drug resistance</searchLink> [Int J Parasitol Drugs Drug Resist] 2019 Apr; Vol. 9, pp. 35-43. <i>Date of Electronic Publication: </i>2019 Jan 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101576715 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2211-3207 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222113207%22">22113207 </searchLink><i>NLM ISO Abbreviation: </i>Int J Parasitol Drugs Drug Resist <i>Subsets: </i>MEDLINE
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