Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.

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Title: Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.
Authors: Brazel DM; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado; Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado., Jiang Y; Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania., Hughey JM; Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania., Turcot V; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada; Montreal Heart Institute, Montreal, Quebec, Canada., Zhan X; Department of Clinical Science, Center for Genetics of Host Defense, University of Texas Southwestern, Dallas, Texas., Gong J; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Batini C; Department of Health Sciences, University of Leicester, Leicester, United Kingdom., Weissenkampen JD; Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania., Liu M; Department of Psychology, University of Minnesota, Minneapolis, Minnesota., Barnes DR; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Bertelsen S; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York., Chou YL; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri., Erzurumluoglu AM; Department of Health Sciences, University of Leicester, Leicester, United Kingdom., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan., Haessler J; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Hammerschlag AR; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, University of Amsterdam, Amsterdam, the Netherlands., Hsu C; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California., Kapoor M; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York., Lai D; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana., Le N; Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois., de Leeuw CA; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, University of Amsterdam, Amsterdam, the Netherlands., Loukola A; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom; National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, United Kingdom., Melbourne CA; Department of Health Sciences, University of Leicester, Leicester, United Kingdom., Pistis G; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy., Qaiser B; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland., Rohde R; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Shao Y; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Stringham H; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan., Wetherill L; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana., Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan., Agrawal A; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri., Bierut L; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri., Chen C; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Epidemiology, Head and Neck Surgery Center, University of Washington, Seattle, Washington; Department of Otolaryngology, Head and Neck Surgery Center, University of Washington, Seattle, Washington., Eaton CB; Department of Family Medicine, Brown University, Providence, Rhode Island., Goate A; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York., Haiman C; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California., Heath A; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri., Iacono WG; Department of Psychology, University of Minnesota, Minneapolis, Minnesota., Martin NG; Queensland Institute for Medical Research, Brisbane, Australia., Polderman TJ; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, University of Amsterdam, Amsterdam, the Netherlands., Reiner A; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Epidemiology, Head and Neck Surgery Center, University of Washington, Seattle, Washington., Rice J; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri; Department of Mathematics, Washington University in St. Louis, St. Louis, Missouri., Schlessinger D; National Institute on Aging, National Institutes of Health, Bethesda, Maryland., Scholte HS; Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, the Netherlands., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan., Tardif JC; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada; Montreal Heart Institute, Montreal, Quebec, Canada., Tindle HA; Department of Medicine, Vanderbilt University, Nashville, Tennessee., van der Leij AR; Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, the Netherlands., Boehnke M; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Cucca F; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy., David SP; Department of Medicine, Stanford University, Stanford, California., Foroud T; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana., Howson JMM; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Kardia SLR; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan., Kooperberg C; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Laakso M; Department of Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Lettre G; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada; Montreal Heart Institute, Montreal, Quebec, Canada., Madden P; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri., McGue M; Department of Psychology, University of Minnesota, Minneapolis, Minnesota., North K; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Posthuma D; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, University of Amsterdam, Amsterdam, the Netherlands; Department of Clinical Genetics, VU University Medical Centre, University of Amsterdam, Amsterdam, the Netherlands., Spector T; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom., Stram D; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California., Tobin MD; Department of Health Sciences, University of Leicester, Leicester, United Kingdom., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan., Kaprio J; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland., Abecasis GR; Regeneron Pharmaceuticals, Tarrytown, New York; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan., Liu DJ; Institute of Personalized Medicine, Penn State College of Medicine, Hershey, Pennsylvania. Electronic address: dajiang.liu@psu.edu., Vrieze S; Department of Psychology, University of Minnesota, Minneapolis, Minnesota. Electronic address: vrieze@umn.edu.
Corporate Authors: CHD Exome+ Consortium, Consortium for Genetics of Smoking Behaviour
Source: Biological psychiatry [Biol Psychiatry] 2019 Jun 01; Vol. 85 (11), pp. 946-955. Date of Electronic Publication: 2018 Dec 06.
Publication Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-2402
DOI:10.1016/j.biopsych.2018.11.024