The human gut bacterial genotoxin colibactin alkylates DNA.
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| Title: | The human gut bacterial genotoxin colibactin alkylates DNA. |
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| Authors: | Wilson MR; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA., Jiang Y; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA., Villalta PW; Masonic Cancer Center, University of Minnesota, 2231 Sixth Street Southeast, Minneapolis, MN 55455, USA., Stornetta A; Masonic Cancer Center, University of Minnesota, 2231 Sixth Street Southeast, Minneapolis, MN 55455, USA., Boudreau PD; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA., Carrá A; Masonic Cancer Center, University of Minnesota, 2231 Sixth Street Southeast, Minneapolis, MN 55455, USA., Brennan CA; Department of Immunology and Infectious Diseases and Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA., Chun E; Department of Immunology and Infectious Diseases and Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA., Ngo L; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA., Samson LD; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA., Engelward BP; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA., Garrett WS; Department of Immunology and Infectious Diseases and Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medical Oncology, Dana-Farber Institute, Boston, MA 02115, USA., Balbo S; Masonic Cancer Center, University of Minnesota, 2231 Sixth Street Southeast, Minneapolis, MN 55455, USA. balskus@chemistry.harvard.edu balbo006@umn.edu., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA. balskus@chemistry.harvard.edu balbo006@umn.edu. |
| Source: | Science (New York, N.Y.) [Science] 2019 Feb 15; Vol. 363 (6428). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.aar7785 |
