Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.

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Title: Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.
Authors: Lin KH; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Xie A; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Rutter JC; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Ahn YR; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Lloyd-Cowden JM; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Nichols AG; Department of Pediatrics, Duke University Medical Center, Durham, NC, USA., Soderquist RS; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Koves TR; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA., Muoio DM; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA., MacIver NJ; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA; Department of Pediatrics, Duke University Medical Center, Durham, NC, USA., Lamba JK; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA., Pardee TS; Department of Internal Medicine, Section on Hematology and Oncology, Wake Forest Baptist Health, Winston-Salem, NC, USA., McCall CM; Department of Pathology, Duke University Medical Center, Durham, NC, USA., Rizzieri DA; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Wood KC; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA. Electronic address: kris.wood@duke.edu.
Source: Cell metabolism [Cell Metab] 2019 May 07; Vol. 29 (5), pp. 1217-1231.e7. Date of Electronic Publication: 2019 Feb 14.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1932-7420
DOI:10.1016/j.cmet.2019.01.011