Precipitation of Soluble Uric Acid Is Necessary for In Vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes.

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Title: Precipitation of Soluble Uric Acid Is Necessary for In Vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes.
Authors: Alberts BM; From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK.; B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex., Barber JS; From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK.; B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex., Sacre SM; From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK.; B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex., Davies KA; From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK.; B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex., Ghezzi P; From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK.; B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex., Mullen LM; From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK. L.Mullen@bsms.ac.uk.; B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex. L.Mullen@bsms.ac.uk.
Source: The Journal of rheumatology [J Rheumatol] 2019 Sep; Vol. 46 (9), pp. 1141-1150. Date of Electronic Publication: 2019 Mar 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Journal Of Rheumatology Publishing Co Country of Publication: Canada NLM ID: 7501984 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1499-2752 (Electronic) Linking ISSN: 0315162X NLM ISO Abbreviation: J Rheumatol Subsets: MEDLINE
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  Data: Precipitation of Soluble Uric Acid Is Necessary for In Vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes.
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  Data: <searchLink fieldCode="AU" term="%22Alberts+BM%22">Alberts BM</searchLink>; From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK.; B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex.<br /><searchLink fieldCode="AU" term="%22Barber+JS%22">Barber JS</searchLink>; From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK.; B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex.<br /><searchLink fieldCode="AU" term="%22Sacre+SM%22">Sacre SM</searchLink>; From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK.; B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex.<br /><searchLink fieldCode="AU" term="%22Davies+KA%22">Davies KA</searchLink>; From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK.; B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex.<br /><searchLink fieldCode="AU" term="%22Ghezzi+P%22">Ghezzi P</searchLink>; From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK.; B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex.<br /><searchLink fieldCode="AU" term="%22Mullen+LM%22">Mullen LM</searchLink>; From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK. L.Mullen@bsms.ac.uk.; B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex. L.Mullen@bsms.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%227501984%22">The Journal of rheumatology</searchLink> [J Rheumatol] 2019 Sep; Vol. 46 (9), pp. 1141-1150. <i>Date of Electronic Publication: </i>2019 Mar 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Journal+Of+Rheumatology+Publishing+Co%22">Journal Of Rheumatology Publishing Co </searchLink><i>Country of Publication: </i>Canada <i>NLM ID: </i>7501984 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1499-2752 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220315162X%22">0315162X </searchLink><i>NLM ISO Abbreviation: </i>J Rheumatol <i>Subsets: </i>MEDLINE
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