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Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model.

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Title: Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model.
Authors: Ionescu A; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978, Israel., Gradus T; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel., Altman T; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel., Maimon R; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel., Saraf Avraham N; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel., Geva M; Teva Pharmaceuticals Ltd, Petah Tikva, Israel.; Prilenia Therapeutics, Herzliya, Israel., Hayden M; Teva Pharmaceuticals Ltd, Petah Tikva, Israel.; Prilenia Therapeutics, Herzliya, Israel., Perlson E; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel. eranpe@tauex.tau.ac.il.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978, Israel. eranpe@tauex.tau.ac.il.
Source: Cell death & disease [Cell Death Dis] 2019 Mar 01; Vol. 10 (3), pp. 210. Date of Electronic Publication: 2019 Mar 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-019-1451-2