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Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.

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Title: Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.
Authors: White JB; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA., Fleming R; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA., Masterson L; b Spirogen Ltd , QMB Innovation Center , London , UK., Ruddle BT; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA., Zhong H; c Oncology Research , MedImmune , Gaithersburg , MD , USA., Fazenbaker C; c Oncology Research , MedImmune , Gaithersburg , MD , USA., Strout P; c Oncology Research , MedImmune , Gaithersburg , MD , USA., Rosenthal K; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA., Reed M; d Biologics Safety Assessment , MedImmune , Gaithersburg , MD , USA., Muniz-Medina V; e Biosuperiors , MedImmune , Gaithersburg , MD , USA., Howard P; b Spirogen Ltd , QMB Innovation Center , London , UK., Dixit R; d Biologics Safety Assessment , MedImmune , Gaithersburg , MD , USA., Wu H; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA., Hinrichs MJ; d Biologics Safety Assessment , MedImmune , Gaithersburg , MD , USA., Gao C; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA., Dimasi N; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA.
Source: MAbs [MAbs] 2019 Apr; Vol. 11 (3), pp. 500-515. Date of Electronic Publication: 2019 Mar 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs
Database: MEDLINE Ultimate
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  Data: Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.
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  Data: <searchLink fieldCode="AU" term="%22White+JB%22">White JB</searchLink>; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA.<br /><searchLink fieldCode="AU" term="%22Fleming+R%22">Fleming R</searchLink>; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA.<br /><searchLink fieldCode="AU" term="%22Masterson+L%22">Masterson L</searchLink>; b Spirogen Ltd , QMB Innovation Center , London , UK.<br /><searchLink fieldCode="AU" term="%22Ruddle+BT%22">Ruddle BT</searchLink>; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA.<br /><searchLink fieldCode="AU" term="%22Zhong+H%22">Zhong H</searchLink>; c Oncology Research , MedImmune , Gaithersburg , MD , USA.<br /><searchLink fieldCode="AU" term="%22Fazenbaker+C%22">Fazenbaker C</searchLink>; c Oncology Research , MedImmune , Gaithersburg , MD , USA.<br /><searchLink fieldCode="AU" term="%22Strout+P%22">Strout P</searchLink>; c Oncology Research , MedImmune , Gaithersburg , MD , USA.<br /><searchLink fieldCode="AU" term="%22Rosenthal+K%22">Rosenthal K</searchLink>; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA.<br /><searchLink fieldCode="AU" term="%22Reed+M%22">Reed M</searchLink>; d Biologics Safety Assessment , MedImmune , Gaithersburg , MD , USA.<br /><searchLink fieldCode="AU" term="%22Muniz-Medina+V%22">Muniz-Medina V</searchLink>; e Biosuperiors , MedImmune , Gaithersburg , MD , USA.<br /><searchLink fieldCode="AU" term="%22Howard+P%22">Howard P</searchLink>; b Spirogen Ltd , QMB Innovation Center , London , UK.<br /><searchLink fieldCode="AU" term="%22Dixit+R%22">Dixit R</searchLink>; d Biologics Safety Assessment , MedImmune , Gaithersburg , MD , USA.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA.<br /><searchLink fieldCode="AU" term="%22Hinrichs+MJ%22">Hinrichs MJ</searchLink>; d Biologics Safety Assessment , MedImmune , Gaithersburg , MD , USA.<br /><searchLink fieldCode="AU" term="%22Gao+C%22">Gao C</searchLink>; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA.<br /><searchLink fieldCode="AU" term="%22Dimasi+N%22">Dimasi N</searchLink>; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA.
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