Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.
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| Title: | Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer. |
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| Authors: | White JB; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA., Fleming R; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA., Masterson L; b Spirogen Ltd , QMB Innovation Center , London , UK., Ruddle BT; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA., Zhong H; c Oncology Research , MedImmune , Gaithersburg , MD , USA., Fazenbaker C; c Oncology Research , MedImmune , Gaithersburg , MD , USA., Strout P; c Oncology Research , MedImmune , Gaithersburg , MD , USA., Rosenthal K; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA., Reed M; d Biologics Safety Assessment , MedImmune , Gaithersburg , MD , USA., Muniz-Medina V; e Biosuperiors , MedImmune , Gaithersburg , MD , USA., Howard P; b Spirogen Ltd , QMB Innovation Center , London , UK., Dixit R; d Biologics Safety Assessment , MedImmune , Gaithersburg , MD , USA., Wu H; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA., Hinrichs MJ; d Biologics Safety Assessment , MedImmune , Gaithersburg , MD , USA., Gao C; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA., Dimasi N; a Antibody Discovery and Protein Engineering , MedImmune , Gaithersburg , MD , USA. |
| Source: | MAbs [MAbs] 2019 Apr; Vol. 11 (3), pp. 500-515. Date of Electronic Publication: 2019 Mar 05. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1942-0870 |
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| DOI: | 10.1080/19420862.2019.1578611 |
