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Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.

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Title: Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.
Authors: Raman S; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada., Beilschmidt M; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada., To M; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada., Lin K; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada., Lui F; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada., Jmeian Y; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada., Ng M; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada., Fernandez M; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada., Fu Y; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada., Mascall K; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada., Duque A; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada., Wang X; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada., Pan G; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada., Angers S; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada., Moffat J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Sidhu SS; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Magram J; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada., Sinclair AM; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada., Fransson J; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada; jfransson@northernbiologics.com jean-philippe.julien@sickkids.ca., Julien JP; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada; jfransson@northernbiologics.com jean-philippe.julien@sickkids.ca.; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Apr 02; Vol. 116 (14), pp. 6812-6817. Date of Electronic Publication: 2019 Mar 20.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.
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  Data: <searchLink fieldCode="AU" term="%22Raman+S%22">Raman S</searchLink>; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Beilschmidt+M%22">Beilschmidt M</searchLink>; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22To+M%22">To M</searchLink>; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Lin+K%22">Lin K</searchLink>; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Lui+F%22">Lui F</searchLink>; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Jmeian+Y%22">Jmeian Y</searchLink>; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Ng+M%22">Ng M</searchLink>; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Fernandez+M%22">Fernandez M</searchLink>; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Fu+Y%22">Fu Y</searchLink>; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Mascall+K%22">Mascall K</searchLink>; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.<br /><searchLink fieldCode="AU" term="%22Duque+A%22">Duque A</searchLink>; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.<br /><searchLink fieldCode="AU" term="%22Pan+G%22">Pan G</searchLink>; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.<br /><searchLink fieldCode="AU" term="%22Angers+S%22">Angers S</searchLink>; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Moffat+J%22">Moffat J</searchLink>; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Sidhu+SS%22">Sidhu SS</searchLink>; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Magram+J%22">Magram J</searchLink>; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Sinclair+AM%22">Sinclair AM</searchLink>; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Fransson+J%22">Fransson J</searchLink>; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada; jfransson@northernbiologics.com jean-philippe.julien@sickkids.ca.<br /><searchLink fieldCode="AU" term="%22Julien+JP%22">Julien JP</searchLink>; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada; jfransson@northernbiologics.com jean-philippe.julien@sickkids.ca.; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2019 Apr 02; Vol. 116 (14), pp. 6812-6817. <i>Date of Electronic Publication: </i>2019 Mar 20.
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