Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities.

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Title: Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities.
Authors: Harmon DB; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., Mandler WK; Department of Physiology and Pharmacology, Health Sciences Center, West Virginia University, Morgantown, WV., Sipula IJ; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., Dedousis N; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., Lewis SE; Department of Physiology and Pharmacology, Health Sciences Center, West Virginia University, Morgantown, WV., Eckels JT; Department of Physiology and Pharmacology, Health Sciences Center, West Virginia University, Morgantown, WV., Du J; Department of Ophthalmology and Biochemistry, Health Sciences Center, West Virginia University, Morgantown, WV., Wang Y; Department of Ophthalmology and Biochemistry, Health Sciences Center, West Virginia University, Morgantown, WV., Huckestein BR; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., Pagano PJ; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute and Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA., Cifuentes-Pagano E; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute and Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA., Homanics GE; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute and Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA.; Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA., Van't Erve TJ; Immunity, Inflammation, and Disease Laboratory/Free Radical Metabolism Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC., Stefanovic-Racic M; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., Jurczak MJ; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., O'Doherty RM; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA eric.kelley@hsc.wvu.edu rmo1@pitt.edu.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., Kelley EE; Department of Physiology and Pharmacology, Health Sciences Center, West Virginia University, Morgantown, WV eric.kelley@hsc.wvu.edu rmo1@pitt.edu.
Source: Diabetes [Diabetes] 2019 Jun; Vol. 68 (6), pp. 1221-1229. Date of Electronic Publication: 2019 Apr 01.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1939-327X
DOI:10.2337/db18-1198