Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities.
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| Title: | Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities. |
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| Authors: | Harmon DB; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., Mandler WK; Department of Physiology and Pharmacology, Health Sciences Center, West Virginia University, Morgantown, WV., Sipula IJ; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., Dedousis N; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., Lewis SE; Department of Physiology and Pharmacology, Health Sciences Center, West Virginia University, Morgantown, WV., Eckels JT; Department of Physiology and Pharmacology, Health Sciences Center, West Virginia University, Morgantown, WV., Du J; Department of Ophthalmology and Biochemistry, Health Sciences Center, West Virginia University, Morgantown, WV., Wang Y; Department of Ophthalmology and Biochemistry, Health Sciences Center, West Virginia University, Morgantown, WV., Huckestein BR; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., Pagano PJ; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute and Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA., Cifuentes-Pagano E; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute and Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA., Homanics GE; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute and Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA.; Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA., Van't Erve TJ; Immunity, Inflammation, and Disease Laboratory/Free Radical Metabolism Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC., Stefanovic-Racic M; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., Jurczak MJ; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., O'Doherty RM; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA eric.kelley@hsc.wvu.edu rmo1@pitt.edu.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA., Kelley EE; Department of Physiology and Pharmacology, Health Sciences Center, West Virginia University, Morgantown, WV eric.kelley@hsc.wvu.edu rmo1@pitt.edu. |
| Source: | Diabetes [Diabetes] 2019 Jun; Vol. 68 (6), pp. 1221-1229. Date of Electronic Publication: 2019 Apr 01. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 30936145 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Harmon+DB%22">Harmon DB</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Mandler+WK%22">Mandler WK</searchLink>; Department of Physiology and Pharmacology, Health Sciences Center, West Virginia University, Morgantown, WV.<br /><searchLink fieldCode="AU" term="%22Sipula+IJ%22">Sipula IJ</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Dedousis+N%22">Dedousis N</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Lewis+SE%22">Lewis SE</searchLink>; Department of Physiology and Pharmacology, Health Sciences Center, West Virginia University, Morgantown, WV.<br /><searchLink fieldCode="AU" term="%22Eckels+JT%22">Eckels JT</searchLink>; Department of Physiology and Pharmacology, Health Sciences Center, West Virginia University, Morgantown, WV.<br /><searchLink fieldCode="AU" term="%22Du+J%22">Du J</searchLink>; Department of Ophthalmology and Biochemistry, Health Sciences Center, West Virginia University, Morgantown, WV.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Ophthalmology and Biochemistry, Health Sciences Center, West Virginia University, Morgantown, WV.<br /><searchLink fieldCode="AU" term="%22Huckestein+BR%22">Huckestein BR</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Pagano+PJ%22">Pagano PJ</searchLink>; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute and Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Cifuentes-Pagano+E%22">Cifuentes-Pagano E</searchLink>; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute and Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Homanics+GE%22">Homanics GE</searchLink>; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute and Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA.; Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Van't+Erve+TJ%22">Van't Erve TJ</searchLink>; Immunity, Inflammation, and Disease Laboratory/Free Radical Metabolism Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC.<br /><searchLink fieldCode="AU" term="%22Stefanovic-Racic+M%22">Stefanovic-Racic M</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Jurczak+MJ%22">Jurczak MJ</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22O'Doherty+RM%22">O'Doherty RM</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA eric.kelley@hsc.wvu.edu rmo1@pitt.edu.; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Kelley+EE%22">Kelley EE</searchLink>; Department of Physiology and Pharmacology, Health Sciences Center, West Virginia University, Morgantown, WV eric.kelley@hsc.wvu.edu rmo1@pitt.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220372763%22">Diabetes</searchLink> [Diabetes] 2019 Jun; Vol. 68 (6), pp. 1221-1229. <i>Date of Electronic Publication: </i>2019 Apr 01. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Diabetes+Association%22">American Diabetes Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372763 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1939-327X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200121797%22">00121797 </searchLink><i>NLM ISO Abbreviation: </i>Diabetes <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=30936145 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.2337/db18-1198 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1221 Titles: – TitleFull: Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Harmon DB – PersonEntity: Name: NameFull: Mandler WK – PersonEntity: Name: NameFull: Sipula IJ – PersonEntity: Name: NameFull: Dedousis N – PersonEntity: Name: NameFull: Lewis SE – PersonEntity: Name: NameFull: Eckels JT – PersonEntity: Name: NameFull: Du J – PersonEntity: Name: NameFull: Wang Y – PersonEntity: Name: NameFull: Huckestein BR – PersonEntity: Name: NameFull: Pagano PJ – PersonEntity: Name: NameFull: Cifuentes-Pagano E – PersonEntity: Name: NameFull: Homanics GE – PersonEntity: Name: NameFull: Van't Erve TJ – PersonEntity: Name: NameFull: Stefanovic-Racic M – PersonEntity: Name: NameFull: Jurczak MJ – PersonEntity: Name: NameFull: O'Doherty RM – PersonEntity: Name: NameFull: Kelley EE IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2019 Jun Type: published Y: 2019 Identifiers: – Type: issn-electronic Value: 1939-327X Numbering: – Type: volume Value: 68 – Type: issue Value: 6 Titles: – TitleFull: Diabetes Type: main |
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