Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis.
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| Title: | Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis. |
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| Authors: | Ma Y; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 4005B Wahl Hall East, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA., Baltezor M; Lead Development Optimization Shared Resource, University of Kansas Cancer Center, Biotechnology Innovation and Optimization Center, Lawrence, KS, USA.; Institute for Advancing Medical Innovation, University of Kansas Medical Center, Kansas City, KS, USA., Rajewski L; Lead Development Optimization Shared Resource, University of Kansas Cancer Center, Biotechnology Innovation and Optimization Center, Lawrence, KS, USA., Crow J; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 4005B Wahl Hall East, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA., Samuel G; Division of Hematology/Oncology, Children's Mercy Kansas City, Kansas City, MO, USA., Staggs VS; Health Services & Outcomes Research, Children's Mercy Kansas City and School of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA., Chastain KM; Division of Hematology/Oncology, Children's Mercy Kansas City, Kansas City, MO, USA., Toretsky JA; Department of Oncology, Georgetown University Medical Center, Washington, D.C., USA., Weir SJ; Institute for Advancing Medical Innovation, University of Kansas Medical Center, Kansas City, KS, USA.; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS, USA., Godwin AK; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 4005B Wahl Hall East, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA. agodwin@kumc.edu.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS, USA. agodwin@kumc.edu. |
| Source: | Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2019 Jul; Vol. 97 (7), pp. 957-972. Date of Electronic Publication: 2019 Apr 25. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer International Country of Publication: Germany NLM ID: 9504370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1440 (Electronic) Linking ISSN: 09462716 NLM ISO Abbreviation: J Mol Med (Berl) Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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