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Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.

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Title: Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.
Authors: Bakowski MA; Calibr at Scripps Research, La Jolla, CA 92037, USA., Shiroodi RK; Calibr at Scripps Research, La Jolla, CA 92037, USA., Liu R; Global Health Drug Discovery Institute (GHDDI), Beijing, China., Olejniczak J; Calibr at Scripps Research, La Jolla, CA 92037, USA., Yang B; Calibr at Scripps Research, La Jolla, CA 92037, USA., Gagaring K; Calibr at Scripps Research, La Jolla, CA 92037, USA., Guo H; Calibr at Scripps Research, La Jolla, CA 92037, USA., White PM; University of California Santa Cruz, Santa Cruz, CA 95064, USA., Chappell L; University of California Santa Cruz, Santa Cruz, CA 95064, USA., Debec A; Jacques Monod Institute, University Paris Diderot/CNRS, 75013 Paris, France., Landmann F; CRBM, University of Montpellier, CNRS, Montpellier, France., Dubben B; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Lenz F; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Struever D; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Ehrens A; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Frohberger SJ; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Sjoberg H; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK., Pionnier N; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK., Murphy E; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK., Archer J; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK., Steven A; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK., Chunda VC; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon., Fombad FF; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon., Chounna PW; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon., Njouendou AJ; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon., Metuge HM; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon., Ndzeshang BL; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon., Gandjui NV; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon., Akumtoh DN; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon., Kwenti TDB; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon., Woods AK; Calibr at Scripps Research, La Jolla, CA 92037, USA., Joseph SB; Calibr at Scripps Research, La Jolla, CA 92037, USA., Hull MV; Calibr at Scripps Research, La Jolla, CA 92037, USA., Xiong W; Global Health Drug Discovery Institute (GHDDI), Beijing, China., Kuhen KL; Calibr at Scripps Research, La Jolla, CA 92037, USA., Taylor MJ; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK., Wanji S; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon., Turner JD; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK., Hübner MP; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Hoerauf A; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Chatterjee AK; Calibr at Scripps Research, La Jolla, CA 92037, USA., Roland J; Calibr at Scripps Research, La Jolla, CA 92037, USA., Tremblay MS; Calibr at Scripps Research, La Jolla, CA 92037, USA., Schultz PG; Calibr at Scripps Research, La Jolla, CA 92037, USA., Sullivan W; University of California Santa Cruz, Santa Cruz, CA 95064, USA., Chu XJ; Global Health Drug Discovery Institute (GHDDI), Beijing, China., Petrassi HM; Calibr at Scripps Research, La Jolla, CA 92037, USA., McNamara CW; Calibr at Scripps Research, La Jolla, CA 92037, USA. cmcnamara@scripps.edu.
Source: Science translational medicine [Sci Transl Med] 2019 May 08; Vol. 11 (491).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.aav3523