Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone.
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| Title: | Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone. |
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| Authors: | Skinner-Adams TS; 1Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111 Australia., Fisher GM; 1Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111 Australia., Riches AG; 2Commonwealth Scientific and Industrial Research Organization, Biomedical Manufacturing, Clayton, VIC 3168 Australia., Hutt OE; 2Commonwealth Scientific and Industrial Research Organization, Biomedical Manufacturing, Clayton, VIC 3168 Australia., Jarvis KE; 2Commonwealth Scientific and Industrial Research Organization, Biomedical Manufacturing, Clayton, VIC 3168 Australia., Wilson T; 2Commonwealth Scientific and Industrial Research Organization, Biomedical Manufacturing, Clayton, VIC 3168 Australia., von Itzstein M; 3Institute for Glycomics, Griffith University Gold Coast Campus, Gold Coast, QLD 4222 Australia., Chopra P; 3Institute for Glycomics, Griffith University Gold Coast Campus, Gold Coast, QLD 4222 Australia., Antonova-Koch Y; School of Medicine, University of California, San Diego, La Jolla, CA 92093 USA.; 7Present Address: California Institute for Biomedical Research (Calibr), La Jolla, CA 92037 USA., Meister S; School of Medicine, University of California, San Diego, La Jolla, CA 92093 USA.; Present Address: Beckman Coulter Life Sciences in Indianapolis, Indianapolis, IN 46268 USA., Winzeler EA; School of Medicine, University of California, San Diego, La Jolla, CA 92093 USA., Clarke M; 1Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111 Australia., Fidock DA; 5Department of Microbiology and Immunology, and Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032 USA., Burrows JN; 6Medicines for Malaria Venture (MMV), Route de Pré Bois 20, Geneva, 1215 Switzerland., Ryan JH; 2Commonwealth Scientific and Industrial Research Organization, Biomedical Manufacturing, Clayton, VIC 3168 Australia., Andrews KT; 1Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111 Australia. |
| Source: | Communications biology [Commun Biol] 2019 May 03; Vol. 2, pp. 166. Date of Electronic Publication: 2019 May 03 (Print Publication: 2019). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: eCollection Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2399-3642 |
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| DOI: | 10.1038/s42003-019-0397-3 |
